Immunogenicity of Immunotoxins Containing

ADP Ribose Transferases / immunology Animals Antibody Formation / immunology Bacterial Toxins / immunology Clinical Trials as Topic Epitopes, B-Lymphocyte / immunology Exotoxins / chemistry Humans Immunoassay Immunomodulation / drug effects Immunotoxins / chemistry Mesothelin Neoplasms / drug therapy Pseudomonas / immunology Recombinant Proteins / immunology Structure-Activity Relationship Treatment Outcome Virulence Factors / immunology Pseudomonas aeruginosa Exotoxin A
B cell epitopes LMB-100 T cell epitopes anti-drug antibodies (ADA) moxetumomab pasudotox neutralizing antibodies recombinant immunotoxins

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 30 03 2020
accepted: 18 05 2020
entrez: 23 7 2020
pubmed: 23 7 2020
medline: 10 4 2021
Statut: epublish

Résumé

Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell.

Identifiants

DOI: 10.3389/fimmu.2020.01261 PMID: 32695104 PMC: PMC7333791
pubmed: 32695104
doi: 10.3389/fimmu.2020.01261
pmc: PMC7333791
doi:

Substances chimiques

Bacterial Toxins 0
Epitopes, B-Lymphocyte 0
Exotoxins 0
Immunotoxins 0
Msln protein, mouse 0
Recombinant Proteins 0
Virulence Factors 0
ADP Ribose Transferases EC 2.4.2.-
Mesothelin J27WDC343N

Types de publication

Journal Article Research Support, N.I.H., Intramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1261

Informations de copyright

Copyright © 2020 Mazor and Pastan.

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Auteurs

Ronit Mazor (R)

Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Ira Pastan (I)

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Eucaryotes › Animaux › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité active › Production d'anticorps › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes B › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Exotoxines › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Immunotoxines › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Mésothéline › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Tumeurs › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Immunogenicity of Immunotoxins Containing
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Facteurs de virulence › Immunogenicity of Immunotoxins Containing