Construction and assessment of the immunogenicity and bactericidal activity of fusion protein porin A from
Adjuvant
Fusion protein
Neisseria meningitidis
Outer membrane vesicle
Porin A
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
23
7
2020
Statut:
ppublish
Résumé
The porins A and B and also outer membrane vesicles (OMVs) of After bioinformatic studies, a fusion protein composed of porin A from both serogroups A and B of Mice received the PorA protein plus Freund's adjuvant. Mice vaccinated with PorA fusion of serogroups A+B plus Freund's adjuvant produced more IgG, IgG1, and IgG2a than combinations admixed with OMV. Furthermore, the vaccinated mice tended to direct the IgG responses toward IgG1. Sera of the mice that received PorA+Freund's and those that received PorA+OMV produced higher bactericidal activity than the controls. Fusion protein porin A could be a valuable target for developing vaccines against
Identifiants
pubmed: 32695289
doi: 10.22038/ijbms.2020.40470.9
pmc: PMC7351441
doi:
Types de publication
Journal Article
Langues
eng
Pagination
737-743Références
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