Indirect effects of severe acute respiratory syndrome coronavirus 2 on the kidney in coronavirus disease patients.
APOL1
COVID-19
SARS-CoV-2
collapsing glomerulopathy
kidney disease
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
20
04
2020
accepted:
28
04
2020
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
23
7
2020
Statut:
epublish
Résumé
Among patients hospitalized for novel coronavirus disease (COVID-19), between 10 and 14% develop an acute kidney injury and around half display marked proteinuria and haematuria. Post-mortem analyses of COVID-19 kidney tissue suggest that renal tubular cells and podocytes are affected. Here we report two cases of collapsing glomerulopathy and tubulointerstitial lesions in living COVID-19 patients. Despite our use of sensitive reverse transcription polymerase chain reaction techniques in this study, we failed to detect the virus in blood, urine and kidney tissues. Our observations suggest that these kidney lesions are probably not due to direct infection of the kidney by severe acute respiratory syndrome coronavirus 2.
Identifiants
pubmed: 32695325
doi: 10.1093/ckj/sfaa088
pii: sfaa088
pmc: PMC7314263
doi:
Types de publication
Journal Article
Langues
eng
Pagination
347-353Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.
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