In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Bioinformatics
Chronic hepatitis B
Genetics
Immunology
In silico
Iran
Microbiology
Molecular biology
Mutations
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
09
12
2019
revised:
23
01
2020
accepted:
24
06
2020
entrez:
23
7
2020
pubmed:
23
7
2020
medline:
23
7
2020
Statut:
epublish
Résumé
Chronic hepatitis B (CHB) virus infection is the most prevalent chronic liver disease and has become a serious threat to human health. In this study, we attempted to specify and predict several properties including physicochemical, mutation sites, B-cell epitopes, phosphorylation sites, N-link, O-link glycosylation sites, and protein structures of S protein isolated from Ahvaz. Initially, hepatitis B virus DNA ( We found major hydrophilic region (MHR) mutations at "a" determining region that included In the present study, mutations were identified at positions T113S and N131T within the MHR region of S protein; these mutations can potentially decrease the effect of hepatitis B vaccination in vaccine recipients.
Identifiants
pubmed: 32695898
doi: 10.1016/j.heliyon.2020.e04332
pii: S2405-8440(20)31176-2
pii: e04332
pmc: PMC7365991
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e04332Informations de copyright
© 2020 The Authors.
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