Formation and Modulation of Nanotubular Assemblies of Oligourea Foldamers in Aqueous Conditions using Alcohol Additives.
alcohols
foldamers
nanotubes
peptidomimetics
self-assembly
Journal
ChemPlusChem
ISSN: 2192-6506
Titre abrégé: Chempluschem
Pays: Germany
ID NLM: 101580948
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
05
2020
revised:
26
06
2020
pubmed:
23
7
2020
medline:
23
7
2020
entrez:
23
7
2020
Statut:
ppublish
Résumé
There is considerable interest in the rational design of controllable, bioinspired supramolecular systems as a potential means to create new biocompatible and functional materials able to mimic and build upon the characteristics of natural biopolymers. Here, the alcohol-controlled aqueous self-assembly of an amphiphilic helical oligourea foldamer (artificial folded oligomer) into a diverse array of tubular fibril architectures is reported. Electron microscopy studies provide details of the morphological evolution of the foldamer nanostructures from protofibrils to fibers, with high resolution X-ray crystal structures providing an atomic-scale view of these assemblies, and solution studies indicating the assembly and morphology to be affected by alcohol polarity and concentration. Overall, the results reported here highlight oligourea foldamers as suitable building blocks for the formation of a diverse range of tubular morphologies in a controllable manner.
Identifiants
pubmed: 32697049
doi: 10.1002/cplu.202000373
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2243-2250Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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