Structural Insights into PROTAC-Mediated Degradation of Bcl-xL.

Benzothiazoles / chemistry Cell Line, Tumor Crystallography, X-Ray Humans Isoquinolines / chemistry Oligopeptides / chemistry Protein Binding Proteolysis / drug effects Von Hippel-Lindau Tumor Suppressor Protein / metabolism bcl-X Protein / antagonists & inhibitors

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
18 09 2020
Historique:
pubmed: 23 7 2020
medline: 9 6 2021
entrez: 23 7 2020
Statut: ppublish

Résumé

The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival. Structural studies of Bcl-xL formed the foundation for the development of the first Bcl-2 family inhibitors and FDA approved drugs. Recently,

Identifiants

DOI: 10.1021/acschembio.0c00266 PMID: 32697072
pubmed: 32697072
doi: 10.1021/acschembio.0c00266
doi:

Substances chimiques

BCL2L1 protein, human 0
Benzothiazoles 0
Isoquinolines 0
Oligopeptides 0
bcl-X Protein 0
Von Hippel-Lindau Tumor Suppressor Protein EC 2.3.2.27
VHL protein, human EC 6.3.2.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2316-2323

Auteurs

Chun-Wa Chung (CW)

Protein, Cellular & Structural Sciences, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0002-2480-3110

Han Dai (H)

Protein Degradation Group, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Esther Fernandez (E)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0002-0507-8507

Christopher P Tinworth (CP)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0002-2756-707X

Ian Churcher (I)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0001-6903-5824

Jenni Cryan (J)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.

Jane Denyer (J)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.

John D Harling (JD)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0003-3602-324X

Agnieszka Konopacka (A)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.

Markus A Queisser (MA)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0002-3368-3827

Christopher J Tame (CJ)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.

Gillian Watt (G)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.

Fan Jiang (F)

Viva Biotech, Ltd., 334 Aidisheng Rd., Zhangjiang High-tech Park, Shanghai 201203, China.

Dongming Qian (D)

Viva Biotech, Ltd., 334 Aidisheng Rd., Zhangjiang High-tech Park, Shanghai 201203, China.

Andrew B Benowitz (AB)

Protein Degradation Group, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
ORCID: 0000-0002-9913-605X

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzothiazoles › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Métabolisme › Protéolyse › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéine Von Hippel-Lindau supresseur de tumeur › Structural Insights into PROTAC-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéine bcl-X › Structural Insights into PROTAC-Mediated...