Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins.
chromosomes
gene expression
genetics
genomics
heritability
human
lipidomics
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
22 07 2020
22 07 2020
Historique:
received:
18
05
2020
accepted:
20
07
2020
pubmed:
23
7
2020
medline:
20
2
2021
entrez:
23
7
2020
Statut:
epublish
Résumé
The critical role of blood lipids in a broad range of health and disease states is well recognised but less explored is the interplay of genetics and environment within the broader blood lipidome. We examined heritability of the plasma lipidome among healthy older-aged twins (75 monozygotic/55 dizygotic pairs) enrolled in the Older Australian Twins Study (OATS) and explored corresponding gene expression and DNA methylation associations. 27/209 lipids (13.3%) detected by liquid chromatography-coupled mass spectrometry (LC-MS) were significantly heritable under the classical ACE twin model (h
Identifiants
pubmed: 32697195
doi: 10.7554/eLife.58954
pii: 58954
pmc: PMC7394543
doi:
pii:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Health and Medical Research Council
ID : 1045325
Pays : International
Organisme : National Health and Medical Research Council
ID : 1085606
Pays : International
Informations de copyright
© 2020, Wong et al.
Déclaration de conflit d'intérêts
MW, AT, NB, KM, YL, LC, BB, NA, JK, PS, MW, DA, RP, TL, AP, PS No competing interests declared
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