Two- and three-dimensional optical coherence tomography to differentiate degenerative changes in a rat meniscectomy model.
3D reconstruction
OCT
articular cartilage
degeneration
quantification
rat
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
15
12
2019
revised:
18
05
2020
accepted:
12
06
2020
pubmed:
23
7
2020
medline:
3
2
2021
entrez:
23
7
2020
Statut:
ppublish
Résumé
Optical coherence tomography (OCT) is an attractive tool for evaluating cartilage. We developed an OCT system that reconstructs and analyzes a three-dimensional (3D) OCT image by determining the cartilage surface and cartilage-bone boundary from the image taken with currently available OCT devices. We examined the usefulness of 3D renderings of OCT images. In a rat meniscectomized model, the tibia was harvested after 0, 2, 4, or 8 weeks (n = 6). We scanned 300 slices in the y-plane to cover a 4 × 3 × 6-mm section (x-plane; 10 µm × 400 pixels, y-plane; 10 µm × 300 pixels, z-plane; 12.66 µm × 500 pixels) of the medial tibial cartilage. The cartilage surface line and the cartilage-bone boundary were plotted semi-automatically. Slices from 300 two-dimensional (2D) sequential images were systematically and visually checked and corrected, as necessary. We set a region of interest in the cartilage and quantified the cartilage volume in the 3D image. The Osteoarthritis Research Society International (OARSI) histological score was also obtained. The cartilage volume determined using 3D OCT images was 0.291 ± 0.022 mm
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2592-2600Informations de copyright
© 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC.
Références
Coker JG, Duker JS. Macular disease and optical coherence tomography. Curr Opin Ophthalmol. 1996;7:33-38.
Brezinski M. Characterizing arterial plaque with optical coherence tomography. Curr Opin Cardiol. 2002;17:648-655.
Matcher SJ. What can biophotonics tell us about the 3D microstructure of articular cartilage? Quant Imaging Med Surg. 2015;5:143-158.
Herrmann JM, Pitris C, Bouma BE, et al. High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography. J Rheumatol. 1999;26:627-635.
Li X, Martin S, Pitris C, et al. High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery. Arthritis Res Ther. 2005;7:R318-323.
Cernohorsky P, Kok AC, Bruin DM, et al. Comparison of optical coherence tomography and histopathology in quantitative assessment of goat talus articular cartilage. Acta Orthop. 2015;86:257-263.
Nebelung S, Marx U, Brill N, et al. Morphometric grading of osteoarthritis by optical coherence tomography-an ex vivo study. J Orthop Res. 2014;32:1381-1388.
Nebelung S, Brill N, Marx U, et al. Three-dimensional imaging and analysis of human cartilage degeneration using optical coherence tomography. J Orthop Res. 2015;33:651-659.
Brill N, Riedel J, Schmitt R, et al. 3D human cartilage surface characterization by optical coherence tomography. Phys Med Biol. 2015;60:7747-7762.
Guermazi A, Alizai H, Crema MD, Trattnig S, Regatte RR, Roemer FW. Compositional MRI techniques for evaluation of cartilage degeneration in osteoarthritis. Osteoarthritis Cartilage. 2015;23:1639-1653.
Tao H, Qiao Y, Hu Y, et al. Quantitative T2-mapping and T2. BioMed Res Int. 2018;2018:7985672.
Chu CR, Williams A, Tolliver D, Kwoh CK, Bruno S, Irrgang JJ. Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears. Arthritis Rheum. 2010;62:1412-1420.
Nebelung S, Brill N, Tingart M, et al. Quantitative OCT and MRI biomarkers for the differentiation of cartilage degeneration. Skeletal Radiol. 2016;45:505-516.
Ozeki N, Muneta T, Matsuta S, et al. Synovial mesenchymal stem cells promote meniscus regeneration augmented by an autologous Achilles tendon graft in a rat partial meniscus defect model. Stem Cells. 2015;33:1927-1938.
Okuno M, Muneta T, Koga H, et al. Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model. J Orthop Res. 2014;32:928-936.
Horie M, Sekiya I, Muneta T, et al. Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect. Stem Cells. 2009;27:878-887.
Pritzker KP, Gay S, Jimenez SA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006;14:13-29.
Puhakka PH, Te Moller NCR, Afara IO, et al. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015;23:2206-2213.
Hall FM, Wyshak G. Thickness of articular cartilage in the normal knee. J Bone Joint Surg Am. 1980;62:408-413.
Brill N, Wirtz M, Merhof D, et al. Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration. J Biomed Opt. 2016;21:76013.
de Bont F, Brill N, Schmitt R, et al. Evaluation of single-impact-induced cartilage degeneration by optical coherence tomography. BioMed Res Int. 2015;2015:486794.