Antiparasitic Activity of Bromotyrosine Alkaloids and New Analogues Isolated from the Fijian Marine Sponge Aplysinella rhax.
Chagas disease
bromotyrosine
malaria
psammaplin
sponge
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
01
05
2020
accepted:
22
07
2020
pubmed:
23
7
2020
medline:
18
5
2021
entrez:
23
7
2020
Statut:
ppublish
Résumé
Ten bromotyrosine alkaloids were isolated and characterised from the marine sponge Aplysinella rhax (de Laubenfels 1954) collected from the Fiji Islands, which included one new bromotyrosine analogue, psammaplin P and two other analogues, psammaplin O and 3-bromo-2-hydroxy-5-(methoxycarbonyl)benzoic acid, which have not been previously reported from natural sources. HR-ESI-MS, 1D and 2D NMR spectroscopic methods were used in the elucidation of the compounds. Bisaprasin, a biphenylic dimer of psammaplin A, showed moderate activity with IC
Identifiants
pubmed: 32697400
doi: 10.1002/cbdv.202000335
doi:
Substances chimiques
Alkaloids
0
Antiprotozoal Agents
0
Biological Products
0
bromotyrosine
0
Tyrosine
42HK56048U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000335Subventions
Organisme : European Union Erasmus+ Programme
Organisme : EU Seventh Framework Programme Project PharmaSea
ID : 312184
Organisme : Fundación MEDINA, Granada, Spain
Informations de copyright
© 2020 The Authors. Chemistry & Biodiversity Published by Wiley-VHCA AG, Zurich, Switzerland.
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