Association of depressive symptom severity with coronary artery calcium: The Dallas heart study.
Depression;Coronary artery calcium;QIDS
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
received:
16
12
2019
revised:
19
06
2020
accepted:
05
07
2020
pubmed:
23
7
2020
medline:
16
2
2021
entrez:
23
7
2020
Statut:
ppublish
Résumé
Previous studies have yielded mixed results regarding the relationship between depressive symptoms and coronary artery calcium (CAC). This analysis sought to evaluate this relationship using a multiethnic, population-based cohort. Data were extracted from the second phase of the Dallas Heart Study (DHS-2). Depressive symptom severity was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS), a validated depressive symptom severity scale. A regression analysis was performed using QIDS score as the predictor variable and CAC as the outcome variable. Covariates included age, sex, ethnicity, diabetes, hypertension, smoking, systolic blood pressure, total cholesterol, HDL cholesterol, and body mass index. The cohort consisted of 2,293 individuals with a mean age of 50 years and included 47.1% female and 47.1% black participants. The mean QIDS score was 4.37(±3.69), and 43.3% had CAC > 0. Regression results indicated that QIDS does not statistically significantly predict whether one does or does not have CAC, when controlling for age, sex, and ethnicity (β = 0.088, p = .240, OR = 1.092, 95% CI 0.943-1.264). Cross sectional design is limited to one point in time, very depressed patients with higher CAC burden may not have participated, and depressive symptoms may be associated with subclinical atherosclerosis differently with a formal diagnosis of depression. Depressive symptoms were not associated with presence or severity of CAC in a multiethnic population based sample. Future studies are needed to determine if other prognostic markers of coronary heart disease are associated with depressive symptoms.
Sections du résumé
BACKGROUND
Previous studies have yielded mixed results regarding the relationship between depressive symptoms and coronary artery calcium (CAC). This analysis sought to evaluate this relationship using a multiethnic, population-based cohort.
METHODS
Data were extracted from the second phase of the Dallas Heart Study (DHS-2). Depressive symptom severity was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS), a validated depressive symptom severity scale. A regression analysis was performed using QIDS score as the predictor variable and CAC as the outcome variable. Covariates included age, sex, ethnicity, diabetes, hypertension, smoking, systolic blood pressure, total cholesterol, HDL cholesterol, and body mass index.
RESULTS
The cohort consisted of 2,293 individuals with a mean age of 50 years and included 47.1% female and 47.1% black participants. The mean QIDS score was 4.37(±3.69), and 43.3% had CAC > 0. Regression results indicated that QIDS does not statistically significantly predict whether one does or does not have CAC, when controlling for age, sex, and ethnicity (β = 0.088, p = .240, OR = 1.092, 95% CI 0.943-1.264).
LIMITATIONS
Cross sectional design is limited to one point in time, very depressed patients with higher CAC burden may not have participated, and depressive symptoms may be associated with subclinical atherosclerosis differently with a formal diagnosis of depression.
CONCLUSION
Depressive symptoms were not associated with presence or severity of CAC in a multiethnic population based sample. Future studies are needed to determine if other prognostic markers of coronary heart disease are associated with depressive symptoms.
Identifiants
pubmed: 32697708
pii: S0165-0327(20)32487-3
doi: 10.1016/j.jad.2020.07.042
pmc: PMC7484243
mid: NIHMS1614643
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
267-271Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001105
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Références
Am J Cardiol. 2016 Jun 15;117(12):1884-9
pubmed: 27138181
JAMA Psychiatry. 2013 Feb;70(2):176-84
pubmed: 23266538
Am J Cardiol. 2016 Feb 1;117(3):325-32
pubmed: 26747734
J Affect Disord. 2013 Sep 25;150(3):736-44
pubmed: 23870425
Atherosclerosis. 2017 Sep;264:92-99
pubmed: 28760375
Arch Gen Psychiatry. 2004 Apr;61(4):369-76
pubmed: 15066895
JAMA Cardiol. 2017 Apr 1;2(4):391-399
pubmed: 28196265
Am J Cardiol. 2016 Jul 15;118(2):183-7
pubmed: 27236256
Prev Cardiol. 2006 Winter;9(1):25-32
pubmed: 16407700
Ann Allergy Asthma Immunol. 2008 May;100(5):433-8
pubmed: 18517074
Prev Med. 2014 Apr;61:54-60
pubmed: 24434161
Am J Cardiol. 2004 Jun 15;93(12):1473-80
pubmed: 15194016
Psychosom Med. 2011 Jan;73(1):7-15
pubmed: 20978226
Circulation. 2001 Nov 27;104(22):2679-84
pubmed: 11723018
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):722-9
pubmed: 20406665
J Cardiovasc Comput Tomogr. 2017 Sep - Oct;11(5):347-353
pubmed: 28732689
Ann Intern Med. 2006 Jun 6;144(11):822-31
pubmed: 16754924
Biol Psychiatry. 2003 Sep 1;54(5):573-83
pubmed: 12946886
Nat Rev Cardiol. 2017 Mar;14(3):145-155
pubmed: 27853162
Circulation. 2013 Sep 3;128(10):1076-84
pubmed: 23884352
Psychosomatics. 2013 Sep-Oct;54(5):458-65
pubmed: 23414849
Psychosom Med. 2009 Feb;71(2):171-86
pubmed: 19188531
N Engl J Med. 2008 Mar 27;358(13):1336-45
pubmed: 18367736
Ann Med. 2009;41(3):224-33
pubmed: 18979272
N Engl J Med. 1999 Jan 14;340(2):115-26
pubmed: 9887164
Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):424-30
pubmed: 11884285
J Psychiatr Res. 2015 Jan;60:132-40
pubmed: 25300442
Psychosom Med. 2006 Sep-Oct;68(5):657-61
pubmed: 17012518
Circulation. 2006 Jan 3;113(1):30-7
pubmed: 16365194
Circulation. 2018 Mar 20;137(12):e67-e492
pubmed: 29386200
Circulation. 2012 Jul 24;126(4):410-7
pubmed: 22711275
J Am Coll Cardiol. 2010 Oct 19;56(17):1397-406
pubmed: 20946997
N Engl J Med. 2000 Nov 2;343(18):1298-304
pubmed: 11058674