Low Absolute Lymphocyte Counts in the Peripheral Blood Predict Inferior Survival and Improve the International Prognostic Index in Testicular Diffuse Large B-Cell Lymphoma.
CNS prophylaxis
absolute lymphocyte count
diffuse large B-cell lymphoma
extranodal lymphoma
lymphopenia
testicular lymphoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
20 Jul 2020
20 Jul 2020
Historique:
received:
17
06
2020
revised:
14
07
2020
accepted:
15
07
2020
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
24
7
2020
Statut:
epublish
Résumé
Low absolute lymphocyte counts (ALC) and high absolute monocyte counts (AMC) are associated with poor survival in patients with diffuse large B-cell lymphoma (DLBCL). We studied the prognostic impact of the ALC and AMC in patients with testicular DLBCL (T-DLBCL). T-DLBCL patients were searched using Southern Finland University Hospital databases and the Danish lymphoma registry. The progression free survival (PFS) and overall survival (OS) were assessed using Kaplan-Meier and Cox proportional hazards methods. We identified 178 T-DLBCL patients, of whom 78 (44%) had a low ALC at diagnosis. The ALC did not correlate with survival in the whole cohort. However, among the patients treated with rituximab (R) containing regimen, a pre-therapeutic low ALC was associated with an increased risk of progression (HR 1.976, 95% CI 1.267-3.086,
Identifiants
pubmed: 32698344
pii: cancers12071967
doi: 10.3390/cancers12071967
pmc: PMC7409117
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Academy of Finland
ID : .
Organisme : Finnish Cancer Organizations
ID : .
Organisme : Sigrid Juselius Foundation
ID : .
Organisme : Karen Elise Jensens Fond
ID : .
Organisme : Helsingin Yliopisto
ID : .
Organisme : Helsingin ja Uudenmaan Sairaanhoitopiiri
ID : .
Organisme : Finnish Oncology Association
ID : .
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