EPA/DHA Concentrate by Urea Complexation Decreases Hyperinsulinemia and Increases Plin5 in the Liver of Mice Fed a High-Fat Diet.
Analysis of Variance
Animals
Body Weight
/ drug effects
Diet, High-Fat
Docosahexaenoic Acids
/ pharmacology
Eicosapentaenoic Acid
/ pharmacology
Feeding Behavior
Fish Oils
/ pharmacology
Hyperinsulinism
/ metabolism
Lipid Droplets
/ chemistry
Liver
/ drug effects
Male
Mice, Inbred C57BL
Oxidation-Reduction
Perilipin-5
/ metabolism
Urea
/ chemistry
EPA + DHA concentration
deodorized refined salmon oil
insulin
metabolic alterations
obesity
perilipins
urea complexation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
20 Jul 2020
20 Jul 2020
Historique:
received:
15
06
2020
revised:
27
06
2020
accepted:
15
07
2020
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Dietary intake of eicosapentaenoic/docosahexaenoic acid (EPA/DHA) reduces insulin resistance and hepatic manifestations through the regulation of metabolism in the liver. Obese mice present insulin resistance and lipid accumulation in intracellular lipid droplets (LDs). LD-associated proteins perilipin (Plin) have an essential role in both adipogenesis and lipolysis; Plin5 regulates lipolysis and thus contributes to fat oxidation. The purpose of this study was to compare the effects of deodorized refined salmon oil (DSO) and its polyunsaturated fatty acids concentrate (CPUFA) containing EPA and DHA, obtained by complexing with urea, on obesity-induced metabolic alteration. CPUFA maximum content was determined using the Box-Behnken experimental design based on Surface Response Methodology. The optimized CPUFA was administered to high-fat diet (HFD)-fed mice (200 mg/kg/day of EPA + DHA) for 8 weeks. No significant differences (
Identifiants
pubmed: 32698439
pii: molecules25143289
doi: 10.3390/molecules25143289
pmc: PMC7397222
pii:
doi:
Substances chimiques
Fish Oils
0
Perilipin-5
0
Plin5 protein, mouse
0
Docosahexaenoic Acids
25167-62-8
Urea
8W8T17847W
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica
ID : 1181774
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