B cell zone reticular cell microenvironments shape CXCL13 gradient formation.
Adaptive Immunity
Animals
B-Lymphocytes
/ cytology
Cathepsin B
/ genetics
Cell Line
Cellular Microenvironment
/ immunology
Chemokine CXCL13
/ immunology
Computer Simulation
Dendritic Cells, Follicular
/ cytology
Extracellular Matrix
/ metabolism
Humans
Mice
Mice, Knockout
Microscopy, Fluorescence
Models, Biological
Palatine Tonsil
/ cytology
Recombinant Proteins
/ genetics
Stromal Cells
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 07 2020
22 07 2020
Historique:
received:
21
04
2018
accepted:
12
03
2020
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms both soluble and immobilized gradients. Specifically, CXCL13
Identifiants
pubmed: 32699279
doi: 10.1038/s41467-020-17135-2
pii: 10.1038/s41467-020-17135-2
pmc: PMC7376062
doi:
Substances chimiques
CXCL13 protein, human
0
Chemokine CXCL13
0
Cxcl13 protein, mouse
0
Recombinant Proteins
0
CTSB protein, human
EC 3.4.22.1
Cathepsin B
EC 3.4.22.1
Ctsb protein, mouse
EC 3.4.22.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3677Subventions
Organisme : Medical Research Council
ID : MR/K021125/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N006453/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F004729/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R001235/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K01580X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15073
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204829
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0601156
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT0905024MA
Pays : United Kingdom
Références
Br J Rheumatol. 1997 Jul;36(7):735-43
pubmed: 9255106
Immunity. 2007 Jul;27(1):160-71
pubmed: 17658276
Nature. 1986 Nov 27-Dec 3;324(6095):369-72
pubmed: 2431318
CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):615-29
pubmed: 26783498
J Immunol. 1999 Jan 15;162(2):1064-70
pubmed: 9916734
Blood. 2013 May 16;121(20):4101-9
pubmed: 23558016
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3849-53
pubmed: 7731994
J Immunol. 2003 Jun 1;170(11):5470-4
pubmed: 12759423
Cell. 2007 Jan 26;128(2):245-56
pubmed: 17254964
J Biol Chem. 2001 Jan 12;276(2):944-51
pubmed: 11016923
Methods Mol Biol. 2017;1591:43-57
pubmed: 28349474
Int Immunol. 2010 Jun;22(6):413-9
pubmed: 20508253
Integr Biol (Camb). 2009 Oct;1(10):602-12
pubmed: 20023777
Nature. 1998 Jun 4;393(6684):440-2
pubmed: 9623998
Nat Rev Immunol. 2009 Jan;9(1):15-27
pubmed: 19079135
Trends Ecol Evol. 1999 Nov;14(11):427-432
pubmed: 10511718
Pharmacol Ther. 2008 Nov;120(2):197-217
pubmed: 18793669
Nat Rev Immunol. 2013 Nov;13(11):815-29
pubmed: 24319779
Annu Rev Biochem. 2005;74:385-410
pubmed: 15952892
Int J Biochem Cell Biol. 2008;40(6-7):1185-98
pubmed: 18243768
Exp Hematol. 2006 Aug;34(8):1021-32
pubmed: 16863908
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2319-2324
pubmed: 28193885
Science. 2010 Apr 23;328(5977):498-501
pubmed: 20413500
Acta Histochem. 2007;109(1):15-28
pubmed: 17224179
Nat Immunol. 2007 Nov;8(11):1255-65
pubmed: 17893676
PLoS Biol. 2016 Jul 14;14(7):e1002515
pubmed: 27415420
Nat Rev Cancer. 2006 Oct;6(10):764-75
pubmed: 16990854
Nat Immunol. 2014 Jul;15(7):623-30
pubmed: 24813163
Nat Immunol. 2007 Sep;8(9):992-1000
pubmed: 17660822
Nat Immunol. 2004 Sep;5(9):943-52
pubmed: 15300245
Biometrika. 1950 Jun;37(1-2):17-23
pubmed: 15420245
FEBS Lett. 2003 Jan 30;535(1-3):55-60
pubmed: 12560078
Nature. 2014 Dec 11;516(7530):254-8
pubmed: 25274307
J Cell Sci. 2012 Oct 1;125(Pt 19):4463-74
pubmed: 22797918
Brain Connect. 2011;1(5):367-75
pubmed: 22432451
Open Biol. 2017 Oct;7(10):
pubmed: 29070611
Nature. 1998 Feb 19;391(6669):799-803
pubmed: 9486651
Nature. 2000 Jul 20;406(6793):309-14
pubmed: 10917533
PLoS Comput Biol. 2013;9(2):e1002916
pubmed: 23468606
J Exp Med. 1998 Feb 16;187(4):655-60
pubmed: 9463416
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 24;368(1611):20120029
pubmed: 23267182
Nat Rev Immunol. 2008 Oct;8(10):764-75
pubmed: 18825130
Faraday Discuss. 2015;184:401-24
pubmed: 26419209
Immunity. 2016 Jan 19;44(1):59-72
pubmed: 26789922
Methods. 2015 Oct 15;88:81-8
pubmed: 25637032
PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3194
pubmed: 25255101
Nucleic Acids Res. 2019 Jan 10;47(1):210-220
pubmed: 30445553
Nature. 2006 Sep 21;443(7109):355-8
pubmed: 16971952
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1885-90
pubmed: 12571364
J Exp Med. 2011 Nov 21;208(12):2497-510
pubmed: 22042977
Methods Enzymol. 1997;287:233-50
pubmed: 9330326
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15376-81
pubmed: 18832162
Immunity. 2010 May 28;32(5):703-13
pubmed: 20471289
Immunity. 2017 Jul 18;47(1):80-92.e4
pubmed: 28709801
Immunity. 2017 Apr 18;46(4):609-620
pubmed: 28389069
Methods Enzymol. 2016;570:87-118
pubmed: 26921943
Biophys J. 2006 Jul 1;91(1):113-21
pubmed: 16603487
J Exp Med. 2000 Jan 3;191(1):61-76
pubmed: 10620605
Biochem Biophys Res Commun. 2016 Sep 2;477(4):602-606
pubmed: 27338641
Cell. 1996 Dec 13;87(6):1037-47
pubmed: 8978608
Pharmaceuticals (Basel). 2017 Aug 09;10(3):
pubmed: 28792472
Front Immunol. 2018 May 22;9:1073
pubmed: 29872430