A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.
Adipose Tissue
/ innervation
Agouti-Related Protein
/ metabolism
Animals
Arcuate Nucleus of Hypothalamus
/ cytology
Brain-Derived Neurotrophic Factor
/ metabolism
Leptin
/ deficiency
Lipolysis
Male
Mice
Mice, Inbred C57BL
Neurons
/ metabolism
Pro-Opiomelanocortin
/ metabolism
Signal Transduction
Subcutaneous Fat
/ innervation
Sympathetic Nervous System
/ physiology
Thermogenesis
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
28
02
2019
accepted:
01
05
2020
pubmed:
24
7
2020
medline:
12
1
2021
entrez:
24
7
2020
Statut:
ppublish
Résumé
Mutations in the leptin gene (ob) result in a metabolic disorder that includes severe obesity
Identifiants
pubmed: 32699414
doi: 10.1038/s41586-020-2527-y
pii: 10.1038/s41586-020-2527-y
doi:
Substances chimiques
Agouti-Related Protein
0
Agrp protein, mouse
0
Brain-Derived Neurotrophic Factor
0
Leptin
0
Pro-Opiomelanocortin
66796-54-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
839-844Références
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