Seizure as the first manifestation of transitional cell carcinoma of the renal pelvis.
brain
metastasis
renal pelvis
urothelial carcinoma
Journal
Journal of surgical case reports
ISSN: 2042-8812
Titre abrégé: J Surg Case Rep
Pays: England
ID NLM: 101560169
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
05
04
2020
accepted:
13
04
2020
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
24
7
2020
Statut:
epublish
Résumé
Upper tract urothelial carcinoma (UTUC) is a rare genitourinary entity of the renal pelvis and the ureter characterized by an aggressive behavior. Cisplatin-based chemotherapy is the first-line therapy of metastatic UTUC. However, a large number of patients with metastatic UTUC are considered ineligible for cisplatin. Immunotherapy emerged as a promising treatment in this setting. Brain metastasis from UTUC is unusual, occurring most often in the presence of systemic metastases. Local therapies such as stereotactic radiosurgery, neurosurgical resection and whole-brain radiotherapy (WBRT) remain the main therapeutic options for brain metastasis. We report a case of a 65-year-old male patient presenting with generalized tonic-clonic seizure. Imaging studies confirmed the presence of multiple brain metastasis. During an evaluation for the primary, he was found to be having metastatic UTUC of the renal pelvis. The brain metastases were treated by hippocampal sparing WBRT with minimal neurotoxicity. The primary tumor was treated by pembrolizumab.
Identifiants
pubmed: 32699589
doi: 10.1093/jscr/rjaa126
pii: rjaa126
pmc: PMC7365028
doi:
Types de publication
Case Reports
Langues
eng
Pagination
rjaa126Informations de copyright
Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.
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