Drug-Induced Immune Hemolytic Anemia due to Amoxicillin-Clavulanate: A Case Report and Review.
amoxicillin-clavulanate
anemia
drug-induced immune hemolytic anemia
hematology
hemolytic anemia
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
17 Jun 2020
17 Jun 2020
Historique:
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
24
7
2020
Statut:
epublish
Résumé
Drug-induced immune hemolytic anemia (DIIHA) is a rare cause of anemia. It is often difficult to distinguish from other causes of hemolytic anemia, thereby delaying diagnosis and treatment. Antibiotics, including penicillins and cephalosporins, are the drugs most often implicated in the development of DIIHA. Discontinuation of the offending agent is often sufficient for treatment. Here, we review the case of a 25-year-old Caucasian female who presented with jaundice and generalized weakness in the setting of outpatient treatment with amoxicillin-clavulanate due to sinus infection. Laboratory testing revealed transaminitis and hemolytic anemia. Direct antiglobulin test (DAT) revealed negative IgG and positive anti-C3. Cold agglutinin titer and Donath-Landsteiner test were negative. The patient was diagnosed with DIIHA most likely due to amoxicillin. She improved with drug cessation and a short course of glucocorticoids. Mechanism of DIIHA, workup, and management are subsequently reviewed.
Identifiants
pubmed: 32699666
doi: 10.7759/cureus.8666
pmc: PMC7370667
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e8666Informations de copyright
Copyright © 2020, Chan Gomez et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Med Clin North Am. 2017 Mar;101(2):351-359
pubmed: 28189175
Blood Rev. 2010 Jul-Sep;24(4-5):143-50
pubmed: 20650555
Immunohematology. 2014;30(2):44-54
pubmed: 25247622
BMC Pharmacol Toxicol. 2018 Oct 25;19(1):67
pubmed: 30359322
Clin Adv Hematol Oncol. 2010 Feb;8(2):98-101
pubmed: 20386530
Br J Haematol. 2017 Apr;177(2):208-220
pubmed: 28369704
Hematology Am Soc Hematol Educ Program. 2009;:73-9
pubmed: 20008184
Am J Clin Pathol. 2011 Jul;136(1):7-12
pubmed: 21685026
Transfus Med Hemother. 2015 Sep;42(5):333-9
pubmed: 26696803
Case Rep Hematol. 2020 Mar 31;2020:9841097
pubmed: 32292611
Blood Transfus. 2014 Jul;12(3):435-7
pubmed: 24887228