First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases.

Alzheimer Disease / drug therapy Cell Line Cell Survival / drug effects Humans Kinetics MicroRNAs / chemistry Molecular Conformation Neuroprotective Agents / chemistry Protein Binding tau Proteins / chemistry

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
20 Aug 2020
Historique:
pubmed: 24 7 2020
medline: 7 4 2021
entrez: 24 7 2020
Statut: ppublish

Résumé

We report a new approach for the development of multitargeted therapeutics for Alzheimer's disease (AD) based on dual targeting of monomeric tau and biogenesis of microRNA-146a. Compound MG-1102 displayed a superior neuroprotective activity, in comparison to mono-targeted therapeutics, which validates the likelihood of the success of this approach in AD drug development.

Identifiants

DOI: 10.1039/d0cc04249h PMID: 32699863
pubmed: 32699863
doi: 10.1039/d0cc04249h
doi:

Substances chimiques

MIRN146 microRNA, human 0
MicroRNAs 0
Neuroprotective Agents 0
tau Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9695-9698

Auteurs

Moustafa T Gabr (MT)

Department of Radiology, Stanford University, Stanford, CA, USA. gabr2003@gmail.com.
ORCID: 0000-0001-9074-3331

Florent Barbault (F)

Universite de Paris, ITODYS, CNRS, UMR 7086, 15 Rue J-A de Baïf, F-75013, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › First dual binder of microRNA-146a and...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › First dual binder of microRNA-146a and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › First dual binder of microRNA-146a and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › First dual binder of microRNA-146a and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › First dual binder of microRNA-146a and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › First dual binder of microRNA-146a and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › First dual binder of microRNA-146a and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › First dual binder of microRNA-146a and...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › First dual binder of microRNA-146a and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › First dual binder of microRNA-146a and...