Emerging themes in idiopathic intracranial hypertension.
Glucagon-like peptide-1 (GLP-1)
Headache
Idiopathic intracranial hypertension
Intracranial pressure
Obesity
Papilloedema
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
18
05
2020
accepted:
15
07
2020
revised:
14
07
2020
pubmed:
24
7
2020
medline:
22
6
2021
entrez:
24
7
2020
Statut:
ppublish
Résumé
Idiopathic intracranial hypertension (IIH) is a rare disorder characterised by raised intracranial pressure. The underlying pathophysiology is mostly unknown and effective treatment is an unmet clinical need in this disease. This review evaluates key emerging themes regarding disease characteristics, mechanisms contributing to raised intracranial pressure and advances in potential therapeutic targets. IIH is becoming more common, with the incidence rising in parallel with the global obesity epidemic. Current medical management remains centred around weight management, which is challenging. Metabolic investigations of patients have identified specific androgen profiles in cerebrospinal fluid (CSF), which suggest an endocrine dysfunction impacting CSF secretion in IIH. Glucagon-like peptide-1 (GLP-1) and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) have been found to play a role in CSF dynamics in IIH and have formed the basis of the first clinical trials looking at new treatments. Identification of novel molecular targets thought to underlie IIH pathology is now being translated to clinical trials.
Identifiants
pubmed: 32700012
doi: 10.1007/s00415-020-10090-4
pii: 10.1007/s00415-020-10090-4
pmc: PMC7674362
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3776-3784Subventions
Organisme : Medical Research Council
ID : G0501747
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Références
JAMA. 2014 Apr 23-30;311(16):1641-51
pubmed: 24756514
JAMA Neurol. 2019 Jul 8;:
pubmed: 31282950
Scientifica (Cairo). 2012;2012:708042
pubmed: 24278732
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
J Neurosci Res. 2017 Jun;95(6):1347-1354
pubmed: 28151589
Arch Dis Child. 2017 Aug;102(8):715-721
pubmed: 28356250
Am J Physiol Renal Physiol. 2009 Dec;297(6):F1647-55
pubmed: 19776173
Neurology. 2009 Jan 27;72(4):304-9
pubmed: 18923135
Eur J Neurol. 2014 Aug;21(8):1055-1059
pubmed: 24698554
Fluids Barriers CNS. 2019 Apr 10;16(1):9
pubmed: 30967147
Neurology. 2013 Sep 24;81(13):1159-65
pubmed: 23966248
J Neurosurg. 2018 Sep;129(3):723-731
pubmed: 28984521
Cephalalgia. 2019 Dec;39(14):1762-1775
pubmed: 31550910
Neurology. 2016 Jan 26;86(4):341-50
pubmed: 26718577
J Biol Chem. 1995 Feb 10;270(6):2427-30
pubmed: 7852300
Lancet Neurol. 2014 Sep;13(9):885-92
pubmed: 25127173
Science. 2001 Dec 7;294(5549):2166-70
pubmed: 11739957
Fluids Barriers CNS. 2020 Feb 10;17(1):10
pubmed: 32036786
Am J Clin Exp Immunol. 2013 Oct 16;2(3):234-44
pubmed: 24179731
J Neurol Neurosurg Psychiatry. 2018 Oct;89(10):1088-1100
pubmed: 29903905
Eur J Neurol. 2018 Oct;25(10):1218-1227
pubmed: 29953685
NPJ Microgravity. 2018 Jan 11;4:1
pubmed: 29354685
Am J Ophthalmol. 2014 Jul;158(1):136-43
pubmed: 24727146
Neurosci Lett. 2017 Apr 3;645:33-39
pubmed: 28219789
BMJ. 2018 Oct 4;363:k3252
pubmed: 30287521
Lancet Neurol. 2016 Jan;15(1):78-91
pubmed: 26700907
J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):982-92
pubmed: 26888960
PLoS One. 2008;3(11):e3799
pubmed: 19030105
Headache. 2009 Feb;49(2):282-5
pubmed: 19222599
Ulster Med J. 2001 May;70(1):31-5
pubmed: 11428322
J Clin Invest. 1998 Feb 1;101(3):515-20
pubmed: 9449682
Headache. 2017 Sep;57(8):1195-1205
pubmed: 28752894
Cephalalgia. 2011 Dec;31(16):1627-33
pubmed: 21968519
Pract Neurol. 2015 Oct;15(5):374-81
pubmed: 26141298
JMIR Res Protoc. 2017 Sep 18;6(9):e181
pubmed: 28923789
Eye (Lond). 2019 Mar;33(3):478-485
pubmed: 30356129
Curr Opin Drug Discov Devel. 2008 Jul;11(4):495-511
pubmed: 18600567
J Pharmacol Exp Ther. 2016 Jan;356(1):223-31
pubmed: 26559125
BMJ Open. 2017 Sep 27;7(9):e017426
pubmed: 28963303
Lancet Neurol. 2014 Nov;13(11):1100-1107
pubmed: 25297013
J Neuroophthalmol. 2016 Mar;36(1):6-12
pubmed: 26618282
Interv Neurol. 2018 Oct;7(6):490-500
pubmed: 30410529
Acta Neurochir (Wien). 2017 Jan;159(1):33-49
pubmed: 27830325
J Neurosurg. 2011 Jan;114(1):34-9
pubmed: 20095788
Curr Opin Neurol. 2019 Feb;32(1):92-98
pubmed: 30547900
J Pain Symptom Manage. 2006 Nov;32(5):401-2
pubmed: 17085265
BMJ. 2010 Jul 07;341:c2701
pubmed: 20610512
Alzheimers Dement. 2016 Feb;12(2):154-163
pubmed: 26368321
BMC Ophthalmol. 2018 Jan 04;17(1):257
pubmed: 29298687
Headache. 2019 Jul;59 Suppl 2:20-32
pubmed: 31291020
Acta Neurol Scand. 2007 Nov;116(5):322-7
pubmed: 17922725
JCI Insight. 2019 Mar 21;4(6):
pubmed: 30753168
Headache. 2017 Sep;57(8):1303-1310
pubmed: 28758206
Lancet Neurol. 2017 Jun;16(6):425-434
pubmed: 28460892
Cephalalgia. 2019 Feb;39(2):245-253
pubmed: 29911422
Graefes Arch Clin Exp Ophthalmol. 2013 Feb;251(2):567-74
pubmed: 22592348
J Clin Endocrinol Metab. 2010 Dec;95(12):5348-56
pubmed: 20826586
J Headache Pain. 2015;16:521
pubmed: 25982204
Headache. 2009 Feb;49(2):185-93
pubmed: 19222592
Neuroophthalmology. 2017 May 10;41(6):326-329
pubmed: 29238388
Horm Mol Biol Clin Investig. 2013 Sep;15(2):37-48
pubmed: 25436731
Eye Brain. 2020 Jan 14;12:1-13
pubmed: 32021528
Arch Neurol. 1993 Jan;50(1):78-80
pubmed: 8418804
J Neuroendocrinol. 2007 Aug;19(8):614-20
pubmed: 17620103
J Neurointerv Surg. 2019 Apr;11(4):380-385
pubmed: 30166333
Cochrane Database Syst Rev. 2015 Aug 07;(8):CD003434
pubmed: 26250102
J Neurol. 2011 May;258(5):874-81
pubmed: 21161260
J Neuroophthalmol. 2018 Dec;38(4):522-530
pubmed: 29985799
J Neuroophthalmol. 2019 Mar;39(1):82-93
pubmed: 30762716
Pract Neurol. 2014 Dec;14(6):380-90
pubmed: 24809339
Cell Metab. 2013 Jun 4;17(6):819-837
pubmed: 23684623
Obes Rev. 2011 May;12(5):e372-80
pubmed: 20804521
Acta Neurol Scand. 2013 Jun;127(6):406-12
pubmed: 23278763
Nat Rev Neurosci. 2015 Aug;16(8):445-57
pubmed: 26174708
Curr Eye Res. 2013 Sep;38(9):972-6
pubmed: 23713489
BMJ Open. 2019 Mar 15;9(3):e026573
pubmed: 30878991
Lancet Neurol. 2015 Nov;14(11):1091-100
pubmed: 26432181
Pract Neurol. 2019 Oct;19(5):399-403
pubmed: 31273078
Neurosci Lett. 1985 Nov 20;62(1):131-6
pubmed: 2415882
Diabetes. 2005 Mar;54(3):872-9
pubmed: 15734867
JAMA Neurol. 2014 Jun;71(6):693-701
pubmed: 24756302
Brain Commun. 2020 Jan 10;2(1):fcz050
pubmed: 32954315
Cephalalgia. 2019 Feb;39(2):209-218
pubmed: 29898611
Headache. 2019 May;59(5):659-681
pubmed: 30982963
AJNR Am J Neuroradiol. 2015 Oct;36(10):1899-904
pubmed: 26251432
Pract Neurol. 2018 Dec;18(6):485-488
pubmed: 30154235
Semin Ophthalmol. 2006 Jan-Mar;21(1):15-7
pubmed: 16517439
J Headache Pain. 2018 Oct 8;19(1):93
pubmed: 30298346
Obes Surg. 2017 Feb;27(2):513-521
pubmed: 27981458
Arch Neurol. 1988 Aug;45(8):875-7
pubmed: 3395261
Sci Transl Med. 2017 Aug 23;9(404):
pubmed: 28835515
Eur J Neurol. 2011 Oct;18(10):1266-8
pubmed: 21426442