Enhancement of a Heroin Vaccine through Hapten Deuteration.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
05 08 2020
05 08 2020
Historique:
pubmed:
24
7
2020
medline:
20
4
2021
entrez:
24
7
2020
Statut:
ppublish
Résumé
The United States is in the midst of an unprecedented epidemic of opioid substance use disorder, and while pharmacotherapies including opioid agonists and antagonists have shown success, they can be inadequate and frequently result in high recidivism. With these challenges facing opioid use disorder treatments immunopharmacotherapy is being explored as an alternative therapy option and is based upon antibody-opioid sequestering to block brain entry. Development of a heroin vaccine has become a major research focal point; however, producing an efficient vaccine against heroin has been particularly challenging because of the need to generate not only a potent immune response but one against heroin and its multiple psychoactive molecules. In this study, we explored the consequence of regioselective deuteration of a heroin hapten and its impact upon the immune response against heroin and its psychoactive metabolites. Deuterium (H
Identifiants
pubmed: 32700530
doi: 10.1021/jacs.0c05219
pmc: PMC7544008
mid: NIHMS1633181
doi:
Substances chimiques
Haptens
0
Vaccines
0
Heroin
70D95007SX
Deuterium
AR09D82C7G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
13294-13298Subventions
Organisme : NIDA NIH HHS
ID : UH3 DA041146
Pays : United States
Références
Drug Alcohol Depend. 2019 Nov 1;204:107501
pubmed: 31479865
Alcohol. 2016 Mar;51:43-9
pubmed: 26992699
Immunol Lett. 2009 Apr 27;123(2):155-9
pubmed: 19428564
J Am Chem Soc. 2013 Feb 27;135(8):2971-4
pubmed: 23398531
Molecules. 2016 May 30;21(6):
pubmed: 27248988
Immunity. 2009 Dec 18;31(6):885-96
pubmed: 20064447
Nature. 1974 Dec 20;252(5485):708-10
pubmed: 4474602
Drug Alcohol Depend. 2014 Jul 1;140:42-7
pubmed: 24793366
Arch Gen Psychiatry. 2009 Oct;66(10):1116-23
pubmed: 19805702
Drug Alcohol Depend. 2013 Sep 1;132(1-2):95-100
pubmed: 23410617
Drug Alcohol Depend. 2007 Sep 6;90(1):64-71
pubmed: 17386981
J Immunol Methods. 2014 Mar;405:74-86
pubmed: 24462800
Vaccine. 2019 Jul 9;37(30):4155-4163
pubmed: 31176539
Clin Plast Surg. 2020 Apr;47(2):181-190
pubmed: 32115045
ACS Omega. 2018 Sep 30;3(9):11537-11543
pubmed: 30288464
Bioorg Med Chem. 2019 Jan 1;27(1):125-132
pubmed: 30497790
Vaccine. 2014 Mar 14;32(13):1473-9
pubmed: 24486371
Hum Vaccin. 2009 Apr;5(4):214-29
pubmed: 19242094
Science. 1972 Dec 22;178(4067):1290-2
pubmed: 4640066
Future Med Chem. 2012 Feb;4(2):227-43
pubmed: 22300100
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11276-80
pubmed: 18685087
J Am Chem Soc. 2017 Jun 28;139(25):8601-8611
pubmed: 28574716
J Pharmacol Exp Ther. 2013 Feb;344(2):397-406
pubmed: 23220743
Ann Intern Med. 2020 Jul 7;173(1):59-60
pubmed: 32240291
CNS Neurol Disord Drug Targets. 2011 Dec;10(8):865-75
pubmed: 22229311
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4337-42
pubmed: 19246393
Pharmacol Rev. 2017 Jul;69(3):298-315
pubmed: 28634286
PLoS One. 2013 Oct 01;8(10):e76557
pubmed: 24098532
Biol Chem. 2003 Aug;384(8):1239-46
pubmed: 12974392
J Immunol. 2011 Mar 1;186(5):2950-8
pubmed: 21282516
Biochem Pharmacol. 2001 Aug 15;62(4):447-55
pubmed: 11448454
Science. 1961 Oct 13;134(3485):1078-9
pubmed: 13889855
Mol Pharm. 2018 Mar 5;15(3):1062-1072
pubmed: 29420901
Mo Med. 2020 Jan-Feb;117(1):59-64
pubmed: 32158052
J Med Chem. 2011 Jul 28;54(14):5195-204
pubmed: 21692508
Adv Pharmacol. 2014;69:553-80
pubmed: 24484987
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9036-41
pubmed: 23650354
ACS Chem Neurosci. 2020 May 6;11(9):1300-1310
pubmed: 32271538
FEBS Lett. 1988 Jul 4;234(1):22-6
pubmed: 2839362
Mol Pharm. 2014 Mar 3;11(3):1075-80
pubmed: 24517171
J Am Chem Soc. 2019 Sep 11;141(36):14089-14092
pubmed: 31479256
ACS Chem Neurosci. 2019 Aug 21;10(8):3409-3414
pubmed: 31268284
Neuropharmacology. 2019 Nov 1;158:107662
pubmed: 31173759
Ann Intern Med. 2020 Jul 7;173(1):57-58
pubmed: 32240283
J Pharmacol Exp Ther. 2009 Oct;331(1):153-61
pubmed: 19541908
J Med Chem. 2019 Jun 13;62(11):5276-5297
pubmed: 30640460
ACS Chem Neurosci. 2018 Jun 20;9(6):1269-1275
pubmed: 29558798
J Med Chem. 2012 Dec 13;55(23):10776-80
pubmed: 23134263
J Am Chem Soc. 2019 Feb 6;141(5):1798-1806
pubmed: 30532973
Front Immunol. 2020 Feb 24;11:283
pubmed: 32153587
Int Immunopharmacol. 2016 Jun;35:137-141
pubmed: 27039212
J Addict. 2020 Mar 12;2020:3956187
pubmed: 32231849