Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020.


Journal

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452

Informations de publication

Date de publication:
Jul 2020
Historique:
entrez: 24 7 2020
pubmed: 24 7 2020
medline: 30 7 2020
Statut: ppublish

Résumé

Serological reactivity was analysed in plasma from 436 individuals with a history of disease compatible with COVID-19, including 256 who had been laboratory-confirmed with SARS-CoV-2 infection. Over 99% of laboratory-confirmed cases developed a measurable antibody response (254/256) and 88% harboured neutralising antibodies (226/256). Antibody levels declined over 3 months following diagnosis, emphasising the importance of the timing of convalescent plasma collections. Binding antibody measurements can inform selection of convalescent plasma donors with high neutralising antibody levels.

Identifiants

pubmed: 32700670
doi: 10.2807/1560-7917.ES.2020.25.28.2001260
pmc: PMC7376844
doi:

Substances chimiques

Antibodies, Neutralizing 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Investigateurs

Stephen Thomas (S)
Sheila MacLennan (S)
Lise Estcourt (L)
Su Brailsford (S)
Hatice Baklan (H)
Kate Tettmar (K)
Jeremy Kellington (J)
Joanne Sell (J)
Gail Miflin (G)

Commentaires et corrections

Type : ErratumIn

Références

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Auteurs

Heli Harvala (H)

Microbiology Services, NHS Blood and Transplant, London, United Kingdom.

Jennifer Mehew (J)

Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom.

Matthew L Robb (ML)

Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom.

Samreen Ijaz (S)

Virology Reference Department, National Infection Service, Public Health England, Colindale Avenue, London, United Kingdom.

Steven Dicks (S)

Microbiology Services, NHS Blood and Transplant, London, United Kingdom.
Virology Reference Department, National Infection Service, Public Health England, Colindale Avenue, London, United Kingdom.

Monika Patel (M)

High Containment Microbiology, National Infection Service, Public Health England, Colindale Avenue, London, United Kingdom.

Nicholas Watkins (N)

NHS Blood and Transplant, Cambridge, United Kingdom.

Peter Simmonds (P)

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Tim Brooks (T)

Rare & Imported Pathogens Laboratory, Public Health England, Porton Down, United Kingdom.

Rachel Johnson (R)

Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom.

Robin Gopal (R)

High Containment Microbiology, National Infection Service, Public Health England, Colindale Avenue, London, United Kingdom.

David J Roberts (DJ)

NHS Blood and Transplant, Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Radcliffe Department of Medicine and BRC Haematology Theme, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Maria Zambon (M)

Virology Reference Department, National Infection Service, Public Health England, Colindale Avenue, London, United Kingdom.
The members of the NHS Blood and Transplant Convalescent Plasma Testing Group are listed below.

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