Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure.
Butylparaben
Development
Reproduction
Toxicity
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
14
04
2020
revised:
01
07
2020
accepted:
14
07
2020
pubmed:
24
7
2020
medline:
8
3
2022
entrez:
24
7
2020
Statut:
ppublish
Résumé
Butylparaben (BP) is an antimicrobial agent utilized for decades as a preservative in numerous consumer products. The safety of parabens has recently come under scrutiny based on reports of estrogenic activity and suggested adverse effects upon the reproductive system. Due to the limited availability of studies that address the potential for BP exposure to induce reproductive toxicity, and clear evidence of human exposure, the National Toxicology Program conducted a multigenerational continuous breeding study to evaluate the impact of dietary BP-exposure at 0, 5000, 15,000, or 40,000 ppm on reproductive and developmental parameters in Hsd:Sprague Dawley SD rats. BP-exposure was not associated with adverse alterations of fertility, fecundity, pubertal attainment, or reproductive parameters in F0, F1, or F2 generations. Exposure-dependent increases in liver weights, and incidences of non-neoplastic liver lesions suggest the liver is a target organ of BP toxicity. No findings were observed that would support the purported mechanism of BP-induced endocrine disruption in perinatally-exposed rodents.
Identifiants
pubmed: 32702374
pii: S0890-6238(20)30180-5
doi: 10.1016/j.reprotox.2020.07.006
pmc: PMC7837387
mid: NIHMS1620406
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Parabens
0
butylparaben
3QPI1U3FV8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
258-272Subventions
Organisme : NIEHS NIH HHS
ID : N01ES75564
Pays : United States
Organisme : NIEHS NIH HHS
ID : HHSN273201600011C
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA ES103316
Pays : United States
Organisme : NIEHS NIH HHS
ID : N01ES55551
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 ES999999
Pays : United States
Informations de copyright
Published by Elsevier Inc.
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