Nosocomial COVID-19 infection: examining the risk of mortality. The COPE-Nosocomial Study (COVID in Older PEople).
Adult
Age Factors
Aged
Aged, 80 and over
Betacoronavirus
COVID-19
Cohort Studies
Coronavirus Infections
/ epidemiology
Cross Infection
/ epidemiology
Female
Frail Elderly
/ statistics & numerical data
Hospital Mortality
Hospitalization
/ statistics & numerical data
Humans
Italy
/ epidemiology
Male
Middle Aged
Pandemics
/ statistics & numerical data
Pneumonia, Viral
/ epidemiology
Proportional Hazards Models
Risk Assessment
/ statistics & numerical data
Risk Factors
SARS-CoV-2
Severity of Illness Index
COVID-19
Community-acquired infection
Nosocomial infection
Journal
The Journal of hospital infection
ISSN: 1532-2939
Titre abrégé: J Hosp Infect
Pays: England
ID NLM: 8007166
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
10
06
2020
accepted:
13
07
2020
pubmed:
24
7
2020
medline:
21
10
2020
entrez:
24
7
2020
Statut:
ppublish
Résumé
Hospital admissions for non-coronavirus disease 2019 (COVID-19) pathology have decreased significantly. It is believed that this may be due to public anxiety about acquiring COVID-19 infection in hospital and the subsequent risk of mortality. To identify patients who acquire COVID-19 in hospital (nosocomial COVID-19 infection (NC)) and their risk of mortality compared to those with community-acquired COVID-19 (CAC) infection. The COPE-Nosocomial Study was an observational cohort study. The primary outcome was the time to all-cause mortality (estimated with an adjusted hazard ratio (aHR)), and secondary outcomes were day 7 mortality and the time-to-discharge. A mixed-effects multivariable Cox's proportional hazards model was used, adjusted for demographics and comorbidities. The study included 1564 patients from 10 hospital sites throughout the UK, and one in Italy, and collected outcomes on patients admitted up to April 28 The minority of COVID-19 cases were the result of NC transmission. No COVID-19 infection comes without risk, but patients with NC had a lower risk of mortality compared to CAC infection; however, caution should be taken when interpreting this finding.
Sections du résumé
BACKGROUND
BACKGROUND
Hospital admissions for non-coronavirus disease 2019 (COVID-19) pathology have decreased significantly. It is believed that this may be due to public anxiety about acquiring COVID-19 infection in hospital and the subsequent risk of mortality.
AIM
OBJECTIVE
To identify patients who acquire COVID-19 in hospital (nosocomial COVID-19 infection (NC)) and their risk of mortality compared to those with community-acquired COVID-19 (CAC) infection.
METHODS
METHODS
The COPE-Nosocomial Study was an observational cohort study. The primary outcome was the time to all-cause mortality (estimated with an adjusted hazard ratio (aHR)), and secondary outcomes were day 7 mortality and the time-to-discharge. A mixed-effects multivariable Cox's proportional hazards model was used, adjusted for demographics and comorbidities.
FINDINGS
RESULTS
The study included 1564 patients from 10 hospital sites throughout the UK, and one in Italy, and collected outcomes on patients admitted up to April 28
CONCLUSION
CONCLUSIONS
The minority of COVID-19 cases were the result of NC transmission. No COVID-19 infection comes without risk, but patients with NC had a lower risk of mortality compared to CAC infection; however, caution should be taken when interpreting this finding.
Identifiants
pubmed: 32702463
pii: S0195-6701(20)30344-3
doi: 10.1016/j.jhin.2020.07.013
pmc: PMC7372282
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
376-384Investigateurs
C Davey
(C)
S Jones
(S)
K Lunstone
(K)
A Cavenagh
(A)
C Silver
(C)
T Telford
(T)
R Simmons
(R)
M Holloway
(M)
J Hesford
(J)
T El Jichi Mutasem
(T)
S Singh
(S)
D Paxton
(D)
W Harris
(W)
N Galbraith
(N)
E Bhatti
(E)
J Edwards
(J)
S Duffy
(S)
J Kelly
(J)
C Murphy
(C)
C Bisset
(C)
R Alexander
(R)
M Garcia
(M)
S Sangani
(S)
T Kneen
(T)
T Lee
(T)
A McGovern
(A)
G Guaraldi
(G)
E Clini
(E)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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