Crystal structure of the AhpD-like protein DR1765 from Deinococcus radiodurans R1.

Bacterial Proteins / chemistry Catalytic Domain Deinococcus / chemistry Hydrogen Peroxide / chemistry Models, Molecular Peroxiredoxins / chemistry Protein Conformation Protein Multimerization
AhpD Alkyl hydroperoxide reductase Antioxidant system D. radiodurans DR1765 crystal structure

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
20 08 2020
Historique:
received: 05 06 2020
accepted: 12 06 2020
entrez: 25 7 2020
pubmed: 25 7 2020
medline: 13 2 2021
Statut: ppublish

Résumé

Deinococcus radiodurans is well known for its extreme resistance to ionizing radiation (IR). Since reactive oxygen species generated by IR can damage various cellular components, D. radiodurans has developed effective antioxidant systems to cope with this oxidative stress. dr1765 from D. radiodurans is predicted to encode an alkyl hydroperoxidase-like protein (AhpD family), which is implicated in the reduction of hydrogen peroxide (H

Identifiants

DOI: 10.1016/j.bbrc.2020.06.061 PMID: 32703449
pubmed: 32703449
pii: S0006-291X(20)31278-X
doi: 10.1016/j.bbrc.2020.06.061
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Hydrogen Peroxide BBX060AN9V
Peroxiredoxins EC 1.11.1.15

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

444-449

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Lei Zhao (L)

Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea; Department of Biotechnology and Bioengineering, Interdisciplinary Program for Bioenergy and Biomaterials, Chonnam National University, Gwangju, 61186, Republic of Korea.

Soyoung Jeong (S)

Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.

Jing Zhang (J)

Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea; Department of Biotechnology and Bioengineering, Interdisciplinary Program for Bioenergy and Biomaterials, Chonnam National University, Gwangju, 61186, Republic of Korea.

Jong-Hyun Jung (JH)

Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea; Department of Radiation Science and Technology, University of Science and Technology, Daejeon, 34113, Republic of Korea.

Jong-Il Choi (JI)

Department of Biotechnology and Bioengineering, Interdisciplinary Program for Bioenergy and Biomaterials, Chonnam National University, Gwangju, 61186, Republic of Korea.

Sangyong Lim (S)

Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea; Department of Radiation Science and Technology, University of Science and Technology, Daejeon, 34113, Republic of Korea. Electronic address: saylim@kaeri.re.kr.

Min-Kyu Kim (MK)

Radiation Research Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea. Electronic address: mkkim@kaeri.re.kr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Deinococcus › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Peroxirédoxines › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Crystal structure of the AhpD-like protein...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Crystal structure of the AhpD-like protein...