Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 07 2020
23 07 2020
Historique:
received:
11
11
2019
accepted:
26
05
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc's associations with excitability, excitability-associated disorders, and myelination.
Identifiants
pubmed: 32704167
doi: 10.1038/s41598-020-69277-4
pii: 10.1038/s41598-020-69277-4
pmc: PMC7378227
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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