A dynamic combinatorial library for biomimetic recognition of dipeptides in water.
artificial receptor
dynamic combinatorial chemistry
dynamic covalent chemistry
molecular recognition
thiolate–disulfide exchange
Journal
Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
04
2020
accepted:
26
06
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
25
7
2020
Statut:
epublish
Résumé
Small peptides are involved in countless biological processes. Hence selective binding motifs for peptides can be powerful tools for labeling or inhibition. Finding those binding motifs, especially in water which competes for intermolecular H-bonds, poses an enormous challenge. A dynamic combinatorial library can be a powerful method to overcome this issue. We previously reported artificial receptors emerging form a dynamic combinatorial library of peptide building blocks. In this study we aimed to broaden this scope towards recognition of small peptides. Employing CXC peptide building blocks, we found that cyclic dimers of oxidized
Identifiants
pubmed: 32704325
doi: 10.3762/bjoc.16.131
pmc: PMC7356556
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1588-1595Informations de copyright
Copyright © 2020, Klepel and Ravoo; licensee Beilstein-Institut.
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