Clinical and Genetic Characteristics of Familial Hypercholesterolemia at Sultan Qaboos University Hospital in Oman.
Acute Coronary Syndrome
Arabs
Cardiovascular Abnormalities
Diabetes Mellitus
Hypercholesterolemia
Oman
Journal
Oman medical journal
ISSN: 1999-768X
Titre abrégé: Oman Med J
Pays: Oman
ID NLM: 101526350
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
21
04
2020
accepted:
10
05
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
25
7
2020
Statut:
epublish
Résumé
We sought to describe the clinical and genetic characteristics of patients with familial hypercholesterolemia (FH) that presented to the lipid clinic at Sultan Qaboos University Hospital, Muscat, Oman. Patients who presented with high low-density lipoprotein cholesterol (LDL-C) levels (> 189.0 mg/dL or 4.9 mmol/L) were recruited to the study. FH was diagnosed according to the Dutch Lipid Clinic Network criteria. Analyses were performed using univariate statistics. The study enrolled 450 patients with a mean age of 48.0±12.0 years, 56.0% (n = 252) were males and 11.3% (n = 51) were smokers. At admission, the proportion of 'probable/definite', 'possible', and 'unlikely' FH were 27.6% (n = 124), 70.0% (n = 315), and 2.4% (n = 11), respectively. Overall, 26.0% (n = 117) of patients had hypertension, 22.4% (n = 101) had a history of coronary artery disease, and 17.3% (n = 78) had diabetes mellitus. Those with 'probable/definite' FH were more likely to be prescribed high-intensity statin therapy (75.8% vs. 54.5%; FH patients are underdiagnosed, undertreated, and less likely to attain their LDL-C goals in Oman.
Identifiants
pubmed: 32704389
doi: 10.5001/omj.2020.59
pii: OMJ-35-03-2000057
pmc: PMC7362724
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e141Informations de copyright
The OMJ is Published Bimonthly and Copyrighted 2020 by the OMSB.
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