Transcriptome analysis reveals a reprogramming energy metabolism-related signature to improve prognosis in colon cancer.
Colon cancer
Metabolism
Overall survival
Reprogramming energy metabolism
Signature
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
02
2020
accepted:
09
06
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
25
7
2020
Statut:
epublish
Résumé
Although much progress has been made to improve treatment, colon cancer remains a leading cause of cancer death worldwide. Metabolic reprogramming is a significant ability of cancer cells to ensure the necessary energy supply in uncontrolled proliferation. Since reprogramming energy metabolism has emerged as a new hallmark of cancer cells, accumulating evidences have suggested that metabolism-related genes may serve as key regulators of tumorigenesis and potential biomarkers. In this study, we analyzed a set of reprogramming energy metabolism-related genes by transcriptome analysis in colon cancer and revealed a five-gene signature that could significantly predict the overall survival. The reprogramming energy metabolism-related signature could distinguish patients into high-risk and low-risk groups with significantly different survival times (
Identifiants
pubmed: 32704448
doi: 10.7717/peerj.9458
pii: 9458
pmc: PMC7350917
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e9458Informations de copyright
©2020 Zhang et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
Références
J Proteome Res. 2015 Aug 7;14(8):3336-47
pubmed: 26136108
PLoS Med. 2013;10(5):e1001453
pubmed: 23700391
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Lancet Oncol. 2019 Feb;20(2):e103-e111
pubmed: 30712797
J Exp Clin Cancer Res. 2018 Jun 28;37(1):127
pubmed: 29954422
Cell Chem Biol. 2017 Sep 21;24(9):1161-1180
pubmed: 28938091
Nat Commun. 2016 Aug 31;7:12619
pubmed: 27577169
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Mol Med Rep. 2018 May;17(5):6387-6396
pubmed: 29512712
Cell Metab. 2019 Mar 5;29(3):576-591
pubmed: 30773467
Carcinogenesis. 2016 Oct;37(10):941-950
pubmed: 27485599
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7131-6
pubmed: 19359472
J Proteome Res. 2015 Mar 6;14(3):1420-31
pubmed: 25643065
Carcinogenesis. 2015 Jul;36(7):710-8
pubmed: 25916654
Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):173-180
pubmed: 29037809
Cancers (Basel). 2014 Feb 10;6(1):366-75
pubmed: 24518611
Curr Drug Metab. 2015;16(3):221-42
pubmed: 26504932
Aging (Albany NY). 2020 Jan 5;12(1):204-223
pubmed: 31905170
Methods. 2010 Apr;50(4):217-26
pubmed: 20025972
Oncotarget. 2017 Jan 10;8(2):2585-2593
pubmed: 27906681
ILAR J. 2017 Jul 1;58(1):17-41
pubmed: 28838066
Crit Rev Oncol Hematol. 2012 Oct;84(1):1-7
pubmed: 22429650
Trends Endocrinol Metab. 2020 Feb;31(2):118-130
pubmed: 31690508
Carcinogenesis. 2016 Sep;37(9):878-887
pubmed: 27287872
BMC Bioinformatics. 2011 Mar 17;12:77
pubmed: 21414208
Mol Oncol. 2018 Nov;12(11):1980-2005
pubmed: 30216655
Oncotarget. 2017 Apr 21;8(35):58172-58183
pubmed: 28938546
Gastroenterology. 2012 Mar;142(3):562-571.e2
pubmed: 22115830
J Adv Pract Oncol. 2016 Jan-Feb;7(1):91-100
pubmed: 27713848
Recent Results Cancer Res. 2016;207:39-72
pubmed: 27557534
BMC Cancer. 2016 Jul 18;16:494
pubmed: 27431388
Tumour Biol. 2015 Jun;36(6):4133-41
pubmed: 25589463
J Transl Med. 2020 Feb 6;18(1):59
pubmed: 32028979
Cell Signal. 2018 Jan;42:97-105
pubmed: 28958617
Proteomics. 2009 Aug;9(15):3889-900
pubmed: 19639598
Anticancer Res. 2015 Nov;35(11):5789-96
pubmed: 26503999
Hum Mol Genet. 2012 Oct 15;21(R1):R97-110
pubmed: 22914737
Sci Rep. 2016 Jan 04;6:18669
pubmed: 26725848
Gastroenterology. 2014 May;146(5):1313-24
pubmed: 24440673
Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):32-42
pubmed: 29883595
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Hepatology. 2013 Dec;58(6):1992-2000
pubmed: 23775819
J Exp Clin Cancer Res. 2015 Oct 06;34:111
pubmed: 26445347
Oncogene. 1997 Feb 13;14(6):629-40
pubmed: 9038370
N Engl J Med. 2016 Jan 21;374(3):277-8
pubmed: 26789877
Semin Cell Dev Biol. 2020 Feb;98:63-70
pubmed: 31129171
Biomed Pharmacother. 2017 Mar;87:8-19
pubmed: 28040600
Gastroenterology. 2010 Mar;138(3):958-68
pubmed: 19914252
Int J Clin Oncol. 2017 Aug;22(4):651-659
pubmed: 28647837
J Dig Dis. 2019 Aug;20(8):391-400
pubmed: 31069993