Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants.
Birth weight
Fetal development
Functional gastrointestinal disorders
Infant, extremely low birth weight
Infant, small for gestational age
Infantile colic
Large for gestational age
Journal
Pediatric gastroenterology, hepatology & nutrition
ISSN: 2234-8646
Titre abrégé: Pediatr Gastroenterol Hepatol Nutr
Pays: Korea (South)
ID NLM: 101590471
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
15
02
2020
revised:
21
04
2020
accepted:
21
04
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
25
7
2020
Statut:
ppublish
Résumé
To assess the association between birth weight and the development of functional gastrointestinal disorders (FGIDs) in the first year of life. This is a secondary analysis of a prospective cohort multicenter study including neonates, consecutively enrolled at birth, and followed up for one year. At birth all infants were classified by birth weight as extremely low (ELBW), very low, or low when <1,000, <1,500, and <2,500 g, respectively, and by birth weight for gestational age as appropriate (AGA, weight in the 10-90th percentile), small (SGA, weight <10th percentile), and large (LGA, weight >90th percentile) for gestational age. FGIDs were classified according to the Rome III criteria and assessed at 1, 3, 6, and 12 months of life. Among 1,152 newborns enrolled, 934 (81.1%) completed the study: 302 (32.3%) were preterm, 35 (3.7%) were ELBW, 104 (11.1%) were SGA, 782 (83.7%) were AGA, and 48 (5.1%) were LGA infants. Overall, throughout the first year of life, 718 (76.9%) reported at least one FGID. The proportion of infants presenting with at least one FGID was significantly higher in ELBW (97%) compared to LBW (74%) ( We observed an increased risk of FGIDs in ELBW, SGA, and LGA neonates. Our results suggest that prenatal factors determining birth weight may influence the development of FGIDs in infants. Understanding the role of all potential risk factors may provide new insights and targeted approaches for FGIDs.
Identifiants
pubmed: 32704497
doi: 10.5223/pghn.2020.23.4.366
pmc: PMC7354866
doi:
Types de publication
Journal Article
Langues
eng
Pagination
366-376Informations de copyright
Copyright © 2020 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no financial conflicts of interest.
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