Brain substrate metabolism and ß-cell function in humans: A positron emission tomography study.
brain glucose uptake
free fatty acids
glucose‐induced potentiation
insulin secretion
positron emission tomography
Journal
Endocrinology, diabetes & metabolism
ISSN: 2398-9238
Titre abrégé: Endocrinol Diabetes Metab
Pays: England
ID NLM: 101732442
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
15
12
2019
revised:
06
03
2020
accepted:
28
03
2020
entrez:
25
7
2020
pubmed:
25
7
2020
medline:
25
7
2020
Statut:
epublish
Résumé
Recent clinical studies have shown enhanced brain glucose uptake during clamp and brain fatty acid uptake in insulin-resistant individuals. Preclinical studies suggest that the brain may be involved in the control of insulin secretion. The aim of this study was to investigate whether brain metabolism assessed as brain glucose and fatty acid uptake is associated with the parameters of β-cell function in humans. We analysed cross-sectional data of 120 subjects across a wide range of BMI and insulin sensitivity. Brain glucose uptake (BGU) was measured during euglycaemic-hyperinsulinaemic clamp (n = 67) and/or during fasting (n = 45) using [ In non-diabetics, BGU during euglycaemic hyperinsulinaemic clamp correlated positively with basal insulin secretion rate ( Our study provides coherent, though correlative, evidence that, in humans, the brain may be involved in the control of insulin secretion independently of insulin sensitivity.
Identifiants
pubmed: 32704559
doi: 10.1002/edm2.136
pii: EDM2136
pmc: PMC7375082
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e00136Informations de copyright
© 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
No potential conflicts of interest relevant to this article were reported.
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