Use of Hantzsch reaction for quantitation of milnacipran as a magic treatment for fibromyalgia syndrome in human plasma and urine.
acetylacetone
fluorimetric
human plasma and urine
milnacipran
Journal
Luminescence : the journal of biological and chemical luminescence
ISSN: 1522-7243
Titre abrégé: Luminescence
Pays: England
ID NLM: 100889025
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
30
05
2020
revised:
07
07
2020
accepted:
19
07
2020
pubmed:
25
7
2020
medline:
29
7
2021
entrez:
25
7
2020
Statut:
ppublish
Résumé
A new fluorimetric procedure is described for analysis of milnacipran in its bulk, tablet dosage forms, as well as in biological human samples such as plasma and urine. The suggested method relies on the construction of a derivative with strong fluorescence called dihydropyridine derivative. This derivative resulted from the interaction of the primary amino group in the studied drug and acetylacetone/formaldehyde in McIlvaine buffer (pH 5). The fluorescent dihydropyridine derivative was measured at 470 nm. Influences of experimental variables namely pH, reagent concentration and temperature were examined and optimized. The calibration curve showed linearity over the range of 0.15-1.25 μg ml
Substances chimiques
Tablets
0
Formaldehyde
1HG84L3525
Milnacipran
G56VK1HF36
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-78Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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