The dose regimen formulation of tilmicosin against Lawsonia intracellularis in pigs by pharmacokinetic-pharmacodynamic (PK-PD) model.

Animals Anti-Bacterial Agents Lawsonia Bacteria Microbial Sensitivity Tests Swine Tylosin / analogs & derivatives
Dosage regimen L. intracellularis Pharmacokinetic-pharmacodynamic (PK-PD) model Pig Tilmicosin

Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 12 04 2020
revised: 11 06 2020
accepted: 07 07 2020
pubmed: 25 7 2020
medline: 22 6 2021
entrez: 25 7 2020
Statut: ppublish

Résumé

In this study, the rational dose regimens of tilmicosin against Lawsonia intracellularis (L. intracellularis) were studied using pharmacokinetic-pharmacodynamic (PK-PD) model approach to provide a maximal efficacy. The healthy and infected pigs were orally administrated the tilmicosin premix at a single dose of 10 mg/kg, and then the plasma and ileum content were collected at different time points. The time to peak (T

Identifiants

DOI: 10.1016/j.micpath.2020.104389 PMID: 32707311
pubmed: 32707311
pii: S0882-4010(20)30755-5
doi: 10.1016/j.micpath.2020.104389
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
tilmicosin XL4103X2E3
Tylosin YEF4JXN031

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104389

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Wanhe Luo (W)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.

Hua Qin (H)

Beijing TEAM Junwei Healthcare Technology Development Co., Ltd., Beijing, 102600, China.

Dongmei Chen (D)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China; MARA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.

Mengru Wu (M)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.

Kuiyu Meng (K)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.

Aoxue Zhang (A)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.

Yunahu Pan (Y)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.

Wei Qu (W)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.

Shuyu Xie (S)

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China. Electronic address: xieshuyu@mail.hzau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The dose regimen formulation of tilmicosin...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › The dose regimen formulation of tilmicosin...
questionsmedicales.fr › Bactéries › Proteobacteria › Deltaproteobacteria › Lawsonia (bactérie) › The dose regimen formulation of tilmicosin...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › The dose regimen formulation of tilmicosin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › The dose regimen formulation of tilmicosin...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Tylosine › The dose regimen formulation of tilmicosin...