Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways.
anticancer
blister beetles
cancer
cantharidin
molecular mechanism
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Jul 2020
19 Jul 2020
Historique:
received:
02
06
2020
revised:
15
07
2020
accepted:
16
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Cancer is a preeminent threat to the human race, causing millions of deaths each year on the Earth. Traditionally, natural compounds are deemed promising agents for cancer treatment. Cantharidin (CTD)-a terpenoid isolated from blister beetles-has been used extensively in traditional Chinese medicines for healing various maladies and cancer. CTD has been proven to be protein phosphatase 2A (PP2A) and heat shock transcription factor 1 (HSF-1) inhibitor, which can be potential targets for its anticancer activity. Albeit, it harbors some toxicities, its immense anticancer potential cannot be overlooked, as the cancer-specific delivery of CTD could help to rescue its lethal effects. Furthermore, several derivatives have been designed to weaken its toxicity. In light of extensive research, the antitumor activity of CTD is evident in both in vitro as well as in vivo cancer models. CTD has also proven efficacious in combination with chemotherapy and radiotherapy and it can also target some drug-resistant cancer cells. This mini-review endeavors to interpret and summarize recent information about CTD anticancer potential and underlying molecular mechanisms. The pertinent anticancer strength of CTD could be employed to develop an effective anticarcinogenic drug.
Identifiants
pubmed: 32707651
pii: molecules25143279
doi: 10.3390/molecules25143279
pmc: PMC7397086
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cantharidin
IGL471WQ8P
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundamental Research Funds for the Central Universities
ID : No. buctrc201910
Organisme : Beijing-Tianjin-Hebei Basic Research Cooperation Special Project
ID : 19JCZDJC65800(Z)
Organisme : grant from the Ministry of Science and Technology of China
ID : 2010ZX09401-403
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