Designing Functionally Versatile, Highly Immunogenic Peptide-Based Multiepitopic Vaccines against Foot-and-Mouth Disease Virus.
click chemistry
foot-and-mouth disease virus
multivalency
peptide-based vaccines
swine host
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
received:
27
05
2020
revised:
02
07
2020
accepted:
16
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously reported solid protection against serotype O FMDV afforded by dendrimeric peptide structures harboring virus-specific B- and T-cell epitopes, and also shown such type of multivalent presentations to be advantageous over simple B-T-epitope linear juxtaposition. Chemically, our vaccine platforms are modular constructions readily made from specified B- and T-cell epitope precursor peptides that are conjugated in solution. With the aim of developing an improved version of our formulations to be used for on-demand vaccine applications, we evaluate in this study a novel design for epitope presentation to the immune system based on a multiple antigen peptide (MAP) containing six immunologically relevant motifs arranged in dendrimeric fashion (named B
Identifiants
pubmed: 32707834
pii: vaccines8030406
doi: 10.3390/vaccines8030406
pmc: PMC7565419
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : AGL2014-48923-C2
Organisme : Ministerio de Ciencia e Innovación
ID : AGL2017-84097-C2-2-R
Organisme : Ministerio de Ciencia e Innovación
ID : AGL2016-349 76445-R
Organisme : Comunidad de Madrid
ID : S2013/ABI-350 2906-PLATESA
Organisme : Comunidad de Madrid
ID : P2018/BAA-4370
Organisme : Generalitat de Catalunya
ID : 2009SGR492
Références
Immunogenetics. 2000 Jul;51(8-9):733-42
pubmed: 10941845
Transbound Emerg Dis. 2008;55(1):5-13
pubmed: 18397505
Curr Top Microbiol Immunol. 2005;288:1-8
pubmed: 15648172
Front Immunol. 2018 Apr 26;9:884
pubmed: 29755468
Transbound Emerg Dis. 2016 Jun;63 Suppl 1:30-41
pubmed: 27320164
Arch Razi Inst. 2018 Dec;73(1):1-10
pubmed: 30256033
J Virol. 1992 Apr;66(4):1835-40
pubmed: 1312607
Vaccines (Basel). 2020 Jan 10;8(1):
pubmed: 31936706
J Gen Virol. 1992 Oct;73 ( Pt 10):2601-7
pubmed: 1328475
Nat Rev Drug Discov. 2007 May;6(5):404-14
pubmed: 17473845
Nature. 1989 Feb 23;337(6209):709-16
pubmed: 2537470
Front Immunol. 2020 Mar 31;11:513
pubmed: 32296430
Clin Vaccine Immunol. 2011 Feb;18(2):280-8
pubmed: 21177918
Transbound Emerg Dis. 2015 Aug;62(4):388-406
pubmed: 24131661
Acta Virol. 2004;48(4):201-14
pubmed: 15745043
PLoS One. 2013 Dec 17;8(12):e84443
pubmed: 24358361
Vaccine. 2006 Apr 24;24(17):3446-56
pubmed: 16522345
Clin Dev Immunol. 2013;2013:475960
pubmed: 24454475
Appl Microbiol Biotechnol. 2015 Feb;99(3):1389-98
pubmed: 25381487
Virology. 2004 May 1;322(2):264-75
pubmed: 15110524
Chem Sci. 2016 Feb 1;7(2):842-854
pubmed: 28791117
Biopolymers. 2001 Feb;58(2):117-28
pubmed: 11093111
ACS Cent Sci. 2018 May 23;4(5):582-589
pubmed: 29806004
Adv Exp Med Biol. 1989;251:175-80
pubmed: 2481959
Chem Soc Rev. 2004 Jan 10;33(1):43-63
pubmed: 14737508
Antiviral Res. 2016 May;129:74-80
pubmed: 26956030
Virol J. 2012 Mar 14;9:66
pubmed: 22416886
Bioconjug Chem. 2013 Apr 17;24(4):578-85
pubmed: 23458489
Front Immunol. 2019 Jul 03;10:1505
pubmed: 31333652
Vaccine. 2002 Jun 7;20(19-20):2603-10
pubmed: 12057619
Science. 1986 May 2;232(4750):639-41
pubmed: 3008333
J Org Chem. 2020 Feb 7;85(3):1626-1634
pubmed: 31782300
J Gen Virol. 1994 Nov;75 ( Pt 11):2937-46
pubmed: 7964603
Clin Microbiol Rev. 2004 Apr;17(2):465-93
pubmed: 15084510
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5409-13
pubmed: 3399498
J Virol. 2008 Jul;82(14):7223-30
pubmed: 18448530
Rev Sci Tech. 2002 Dec;21(3):637-44
pubmed: 12523703
Transbound Emerg Dis. 2020 Jul;67(4):1614-1622
pubmed: 31994334
Nature. 1982 Jul 1;298(5869):30-3
pubmed: 7045684
Virus Res. 2017 Jun 15;238:8-12
pubmed: 28571760
Rev Sci Tech. 2002 Dec;21(3):459-63
pubmed: 12523687
J Immunol Methods. 1996 Sep 13;196(1):17-32
pubmed: 8841440
Chem Rev. 2020 Mar 25;120(6):3210-3229
pubmed: 31804810
Gene. 2018 May 5;653:91-101
pubmed: 29432828
Virol Sin. 2011 Jun;26(3):190-7
pubmed: 21667339
EMBO J. 1982;1(7):869-74
pubmed: 6203738
Science. 1993 Nov 26;262(5138):1448-51
pubmed: 8248784