Receptor-Associated Prorenin System in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma and Neovascular Glaucoma.
(pro)renin receptor
angiogenesis
angiotensin II type 1 receptor
neovascular glaucoma
primary open-angle glaucoma
prorenin
receptor-associated prorenin system
renin-angiotensin system
tissue remodeling
trabecular meshwork
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
received:
28
05
2020
revised:
13
07
2020
accepted:
21
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
The receptor-associated prorenin system (RAPS) is associated with several pathologic conditions, including diabetic retinopathy, age-related macular degeneration, and uveitis. Here, we show the involvement of RAPS in the trabecular meshwork (TM) from patients with primary open-angle glaucoma (POAG) and neovascular glaucoma (NVG) due to proliferative diabetic retinopathy. Anterior chamber (AC) levels of prorenin significantly increased in both POAG and NVG, as did those of angiotensin II in NVG alone, compared to cataract. In surgically excised TM tissues, (pro)renin receptor ((P)RR) and angiotensin II type 1 receptor (AT1R) co-localized with prorenin and angiotensinogen, respectively. In screening for various genes related to glaucoma, prorenin stimulation to human TM cells exclusively upregulated cell junction constituents
Identifiants
pubmed: 32707887
pii: jcm9082336
doi: 10.3390/jcm9082336
pmc: PMC7465309
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Education, Science and Culture of Japan
ID : 16K11279
Organisme : Ministry of Education, Science and Culture of Japan
ID : 16H05484
Organisme : Bayer Japan Retina Award
ID : none
Organisme : Institute of Science of Blood Pressure and Hormone
ID : none
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