Clinical Utility of Plasma Lipid Peroxidation Biomarkers in Alzheimer's Disease Differential Diagnosis.
Alzheimer’s disease
clinical validation
differential diagnosis
lipid peroxidation
plasma
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
received:
26
06
2020
revised:
15
07
2020
accepted:
21
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Differential diagnosis of Alzheimer's disease (AD) is a complex task due to the clinical similarity among neurodegenerative diseases. Previous studies showed the role of lipid peroxidation in early AD development. However, the clinical validation of potential specific biomarkers in minimally invasive samples constitutes a great challenge in early AD diagnosis. Plasma samples from participants classified into AD ( A two-step diagnosis model was developed from plasma lipid peroxidation products to diagnose early AD specifically, and a bootstrap validated AUC of 0.74 was obtained. A promising AD differential diagnosis model was developed. It was clinically validated as a screening test. However, further external validation is required before clinical application.
Sections du résumé
BACKGROUND
BACKGROUND
Differential diagnosis of Alzheimer's disease (AD) is a complex task due to the clinical similarity among neurodegenerative diseases. Previous studies showed the role of lipid peroxidation in early AD development. However, the clinical validation of potential specific biomarkers in minimally invasive samples constitutes a great challenge in early AD diagnosis.
METHODS
METHODS
Plasma samples from participants classified into AD (
RESULTS
RESULTS
A two-step diagnosis model was developed from plasma lipid peroxidation products to diagnose early AD specifically, and a bootstrap validated AUC of 0.74 was obtained.
CONCLUSION
CONCLUSIONS
A promising AD differential diagnosis model was developed. It was clinically validated as a screening test. However, further external validation is required before clinical application.
Identifiants
pubmed: 32707935
pii: antiox9080649
doi: 10.3390/antiox9080649
pmc: PMC7464465
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : CP16/00082
Références
Alzheimers Dement. 2019 Jun;15(6):764-775
pubmed: 31113759
PLoS One. 2011;6(8):e23112
pubmed: 21826230
Neurobiol Aging. 2017 Oct;58:225-237
pubmed: 28716532
Free Radic Biol Med. 1999 Aug;27(3-4):463-9
pubmed: 10468223
J Alzheimers Dis. 2011;26(1):59-68
pubmed: 21593563
Neuroimage Clin. 2019;24:101941
pubmed: 31376643
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9693-9700
pubmed: 32013375
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Curr Alzheimer Res. 2019;16(7):587-595
pubmed: 31345148
Acta Neuropathol. 2018 Dec;136(6):821-853
pubmed: 30488277
Curr Pharm Des. 2018;24(40):4771-4778
pubmed: 30767733
Chemistry. 2015 Feb 2;21(6):2442-6
pubmed: 25504325
Exp Gerontol. 2019 Aug;123:10-16
pubmed: 31117002
Curr Alzheimer Res. 2019;16(6):518-528
pubmed: 31099321
Anal Chem. 2014 Dec 16;86(24):12047-54
pubmed: 25415602
Exp Brain Res. 2018 May;236(5):1241-1250
pubmed: 29480353
Biol Trace Elem Res. 2014 May;158(2):158-65
pubmed: 24682919
Nat Rev Neurol. 2010 Mar;6(3):131-44
pubmed: 20157306
Alzheimers Dement. 2019 Nov;15(11):1478-1488
pubmed: 31495601
Physiol Res. 2017 Dec 20;66(6):1049-1056
pubmed: 28937243
Alzheimers Dement (Amst). 2017 May 18;8:111-126
pubmed: 28603768
Dialogues Clin Neurosci. 2007;9(2):153-60
pubmed: 17726914
Exp Neurobiol. 2015 Dec;24(4):325-40
pubmed: 26713080
Rejuvenation Res. 2010 Apr-Jun;13(2-3):301-13
pubmed: 20462385
Alzheimers Dement. 2019 Jun;15(6):776-787
pubmed: 31047856
Dement Geriatr Cogn Disord. 2004;18(3-4):265-70
pubmed: 15286458
Alzheimers Dement. 2016 Jul;12(7):815-22
pubmed: 26806385
Neurodegener Dis. 2010;7(1-3):139-42
pubmed: 20197693
Alzheimers Dement. 2019 Aug;15(8):1059-1070
pubmed: 31201098
Nat Rev Neurol. 2018 Nov;14(11):639-652
pubmed: 30297701
ACS Chem Neurosci. 2012 Nov 21;3(11):928-40
pubmed: 23173073
Curr Neuropharmacol. 2019;17(7):630-647
pubmed: 30255758
Br J Psychiatry. 1982 Jun;140:566-72
pubmed: 7104545
Alzheimers Dement. 2014 Mar;10(2):e47-92
pubmed: 24818261
J Cell Mol Med. 2016 Jul;20(7):1367-72
pubmed: 26991927
Alzheimers Dement (Amst). 2019 Sep 06;11:646-653
pubmed: 31517027
J Neurochem. 2019 Jul;150(2):218-230
pubmed: 31077373
Oxid Med Cell Longev. 2019 Jun 23;2019:7092151
pubmed: 31341533
Talanta. 2018 Jul 1;184:193-201
pubmed: 29674032
J Clin Exp Neuropsychol. 1998 Jun;20(3):310-9
pubmed: 9845158
Front Public Health. 2016 May 25;4:94
pubmed: 27252937
J Neurol Sci. 2002 Nov 15;203-204:29-34
pubmed: 12417353
Alzheimers Dement. 2019 Oct;15(10):1367-1377
pubmed: 31548122
PLoS One. 2018 May 10;13(5):e0197329
pubmed: 29746584
QJM. 2001 Sep;94(9):485-90
pubmed: 11528012
Int J Neurosci. 2017 Dec;127(12):1082-1086
pubmed: 28504037
Nat Rev Drug Discov. 2010 Jul;9(7):560-74
pubmed: 20592748
Mol Neurobiol. 2016 Jan;53(1):648-661
pubmed: 25511446
J Neurosci. 2008 Apr 30;28(18):4785-94
pubmed: 18448655
Exp Gerontol. 2012 Aug;47(8):625-30
pubmed: 22664577
Nutrition. 2016 Feb;32(2):193-8
pubmed: 26690564
Geriatr Gerontol Int. 2010 Apr;10(2):161-6
pubmed: 20446930
Free Radic Biol Med. 2018 Aug 20;124:388-394
pubmed: 29969716
Arch Neurol. 2002 Nov;59(11):1737-46
pubmed: 12433261
IEEE Trans Image Process. 2017 Mar;26(3):1466-1481
pubmed: 28092552
Clin Chim Acta. 2019 Apr;491:85-90
pubmed: 30685358
Neurobiol Aging. 2015 Feb;36(2):812-20
pubmed: 25457549
Free Radic Biol Med. 2013 Sep;62:157-169
pubmed: 23044265
Int J Alzheimers Dis. 2010 Jun 23;2010:
pubmed: 20721349
Oxid Med Cell Longev. 2017;2017:7156928
pubmed: 28811866
Alzheimers Dement. 2015 Jan;11(1):58-69
pubmed: 24795085
Geriatr Gerontol Int. 2016 Dec;16(12):1312-1318
pubmed: 26531676
J Neurosci. 2001 Jun 15;21(12):4183-7
pubmed: 11404403