Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research.
biomedicine
biosecurity
cone snail
conopeptide
conotoxin
drugs
envenomations
fatalities
venom
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
22 Jul 2020
22 Jul 2020
Historique:
received:
30
06
2020
revised:
17
07
2020
accepted:
19
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits. These include their use as a drug, diagnostic agent, drug leads, and research tools in neuroscience, pharmacology, biochemistry, structural biology, and molecular evolution. Human envenomations by cone snails are rare but can be fatal. Death by envenomation is likely caused by a small set of toxins that induce muscle paralysis of the diaphragm, resulting in respiratory arrest. The potency of these toxins led to concerns regarding the potential development and use of conotoxins as biological weapons. To address this, various regulatory measures have been introduced that limit the use and access of conotoxins within the research community. Some of these regulations apply to all of the ≈200,000 conotoxins predicted to exist in nature of which less than 0.05% are estimated to have any significant toxicity in humans. In this review we provide an overview of the many benefits of conotoxin research, and contrast these to the perceived biosecurity concerns of conotoxins and research thereof.
Identifiants
pubmed: 32708023
pii: biomedicines8080235
doi: 10.3390/biomedicines8080235
pmc: PMC7460000
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIH HHS
ID : GM103801
Pays : United States
Organisme : Velux Fonden
ID : 19063
Organisme : NCATS NIH HHS
ID : UL1 TR002538
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM048677
Pays : United States
Organisme : NIH HHS
ID : GM122869
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136430
Pays : United States
Organisme : U.S. Department of Defense
ID : W81XWH170413
Organisme : Det Frie Forskningsråd
ID : 7017-00288
Organisme : NIGMS NIH HHS
ID : R01 GM103801
Pays : United States
Organisme : NIH HHS
ID : GM136430
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM122869
Pays : United States
Références
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13767-72
pubmed: 16162671
Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2:14562-8
pubmed: 14573706
BMC Evol Biol. 2016 Jan 28;16:27
pubmed: 26818019
Br J Pharmacol. 1999 Feb;126(3):581-4
pubmed: 10188967
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2319-24
pubmed: 24469798
J Neurosci. 1985 Jan;5(1):110-6
pubmed: 2981295
Neuron. 1992 Dec;9(6):1099-115
pubmed: 1334419
Expert Opin Biol Ther. 2011 Nov;11(11):1469-84
pubmed: 21939428
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4327-31
pubmed: 2438698
Mol Biol Evol. 2018 May 1;35(5):1210-1224
pubmed: 29514313
Toxicon. 2001 Oct;39(10):1447-51
pubmed: 11478951
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1388-95
pubmed: 22307590
Mol Biol Evol. 2012 Aug;29(8):2019-29
pubmed: 22337864
Biochem Pharmacol. 2009 Oct 1;78(7):693-702
pubmed: 19477168
Science. 2001 Oct 12;294(5541):333-9
pubmed: 11598293
J Biol Chem. 2019 May 31;294(22):8745-8759
pubmed: 30975904
Toxins (Basel). 2017 Jul 28;9(8):
pubmed: 28788055
Br J Pharmacol. 2012 Jul;166(5):1654-68
pubmed: 22229737
Sci Signal. 2019 Sep 24;12(600):
pubmed: 31551295
Science. 2014 Aug 29;345(6200):1021-6
pubmed: 25103405
Neuropsychopharmacology. 2011 Apr;36(5):1021-32
pubmed: 21289604
Lancet. 1989 Sep 16;2(8664):640-3
pubmed: 2570899
Semin Neurol. 2004 Jun;24(2):149-53
pubmed: 15257511
AAPS J. 2015 Jan;17(1):134-43
pubmed: 25366889
Immunobiology. 2016 Jul;221(7):761-72
pubmed: 26965141
Biochemistry. 1998 Feb 10;37(6):1470-7
pubmed: 9484216
Curr Med Chem. 2004 Dec;11(23):3029-40
pubmed: 15578997
Int J Pept Protein Res. 1989 Dec;34(6):455-62
pubmed: 2635691
J Biol Chem. 2002 Sep 13;277(37):33610-5
pubmed: 12114524
Toxicon. 2015 Jan;93:85-9
pubmed: 25450799
J Neurochem. 1999 Aug;73(2):849-58
pubmed: 10428084
Biochemistry. 1989 Apr 18;28(8):3437-42
pubmed: 2545259
FEBS J. 2005 Apr;272(7):1727-38
pubmed: 15794759
Acta Trop. 2008 Aug;107(2):71-9
pubmed: 18579104
Ann Neurol. 1991 Mar;29(3):307-14
pubmed: 1645944
Drug Discov Today. 2015 Jan;20(1):122-8
pubmed: 25450771
Front Pharmacol. 2019 Jan 07;9:1499
pubmed: 30687084
Neuropharmacology. 2017 Dec;127:79-86
pubmed: 28689026
Eur J Neurol. 2010 Jul;17(7):893-902
pubmed: 20402760
Sci Rep. 2017 Aug 3;7(1):7202
pubmed: 28775316
Bioorg Med Chem. 2018 Jun 1;26(10):2738-2758
pubmed: 28988749
Toxicon. 1981;19(5):691-9
pubmed: 6895426
J Biol Chem. 1987 Nov 25;262(33):15821-4
pubmed: 3680228
Org Lett. 2015 Oct 16;17(20):4933-5
pubmed: 26421741
Expert Opin Drug Saf. 2012 Mar;11(2):315-24
pubmed: 22233272
Molecules. 2018 Aug 08;23(8):
pubmed: 30096783
J Mol Evol. 2010 Feb;70(2):190-202
pubmed: 20143226
Nat Med. 2005 Sep;11(9):973-81
pubmed: 16116433
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12758-63
pubmed: 22778416
Curr Top Med Chem. 2012;12(8):845-51
pubmed: 22352912
J Biol Chem. 1998 Mar 6;273(10):5447-50
pubmed: 9488665
Semin Cell Dev Biol. 2019 Oct;94:20-27
pubmed: 30658154
Mol Phylogenet Evol. 2014 Sep;78:290-303
pubmed: 24878223
Angew Chem Int Ed Engl. 2010 Sep 3;49(37):6545-8
pubmed: 20533477
Toxicon. 1991;29(9):1115-27
pubmed: 1665604
Brain Res. 2005 Oct 19;1059(2):149-58
pubmed: 16182258
Neuromodulation. 2017 Feb;20(2):96-132
pubmed: 28042904
J Biol Chem. 2010 Apr 23;285(17):12735-46
pubmed: 20147296
Biochemistry. 2006 Feb 7;45(5):1511-7
pubmed: 16445293
Physiol Rev. 2004 Jan;84(1):41-68
pubmed: 14715910
Science. 1998 Jul 24;281(5376):575-8
pubmed: 9677203
Microb Cell Fact. 2017 Jan 17;16(1):6
pubmed: 28095880
Nat Neurosci. 2001 Sep;4(9):902-7
pubmed: 11528421
Nat Struct Mol Biol. 2020 Jul;27(7):615-624
pubmed: 32483339
Neurosci Lett. 2018 Jul 13;679:24-34
pubmed: 29199094
Science. 1971 Apr 30;172(3982):495-8
pubmed: 4396320
Mol Biol Evol. 2018 Oct 1;35(10):2355-2374
pubmed: 30032303
Neuropsychopharmacology. 2015 Jan;40(2):350-60
pubmed: 25035086
Pain. 2014 Oct;155(10):1986-95
pubmed: 25008370
Nature. 1996 May 9;381(6578):148-51
pubmed: 12074021
Nature. 1984 Mar 15-21;308(5956):282-4
pubmed: 6608056
Biochim Biophys Acta. 1987 Sep 24;915(2):210-6
pubmed: 3651474
J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):85-7
pubmed: 7823075
J Neurochem. 2003 May;85(3):610-21
pubmed: 12694387
Diving Hyperb Med. 2015 Sep;45(3):200-7
pubmed: 26415072
N Engl J Med. 1995 Jun 1;332(22):1467-74
pubmed: 7739683
J Biochem. 1988 Aug;104(2):184-7
pubmed: 3182760
Nat Struct Mol Biol. 2016 Oct;23(10):916-920
pubmed: 27617429
Circ Res. 2007 Feb 16;100(3):342-53
pubmed: 17307972
Microb Cell Fact. 2017 Jan 17;16(1):4
pubmed: 28093085
Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20201-20209
pubmed: 31530723
Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976
pubmed: 28984021
Respir Res. 2001;2(4):198-209
pubmed: 11686885
Nat Rev Neurosci. 2010 Dec;11(12):823-36
pubmed: 21068766
J Biol Chem. 1985 Aug 5;260(16):9280-8
pubmed: 2410412
Elife. 2019 Feb 12;8:
pubmed: 30747102
J Mol Evol. 2012 Jun;74(5-6):297-309
pubmed: 22760645
Nephrol Dial Transplant. 1997 Nov;12(11):2244-50
pubmed: 9394306
Syst Rev. 2017 Apr 8;6(1):74
pubmed: 28390429
Sci Signal. 2014 Oct 07;7(346):ra94
pubmed: 25292213
Curr Biol. 2009 Jun 9;19(11):900-8
pubmed: 19481459
Br J Haematol. 2017 Jun;177(6):947-959
pubmed: 28233897
Mol Biol Evol. 2016 Nov;33(11):2924-2934
pubmed: 27524826
Toxins (Basel). 2018 Dec 01;10(12):
pubmed: 30513724
Proc Natl Acad Sci U S A. 1956 Mar;42(3):168-71
pubmed: 16589843
J Proteomics. 2019 Jan 6;190:12-20
pubmed: 29777871
J Am Chem Soc. 1968 Mar 27;90(7):1917-8
pubmed: 5689118
Toxins (Basel). 2020 Mar 21;12(3):
pubmed: 32245200
Biochemistry. 2004 Feb 3;43(4):1093-101
pubmed: 14744155
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6820-3
pubmed: 10359796
Acta Pharmacol Sin. 2009 Jun;30(6):771-83
pubmed: 19448650
Brain Behav Evol. 2015 Sep;86(1):58-74
pubmed: 26397110
Front Immunol. 2018 Jul 30;9:1604
pubmed: 30105015
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17880-4
pubmed: 17101979
Epilepsy Res. 2019 Aug;154:132-138
pubmed: 31132598
J Toxicol Clin Toxicol. 1983-1984;21(4-5):527-55
pubmed: 6147420
J Neurochem. 1999 Apr;72(4):1656-62
pubmed: 10098874
Pharm Res. 1990 Jun;7(6):565-9
pubmed: 2114618
Ann N Y Acad Sci. 1960 Nov 17;90:706-25
pubmed: 13757593
Toxicon. 2015 Jan;93:125-35
pubmed: 25432067
Biomed Res Int. 2017;2017:6592820
pubmed: 29318152
J Biol Chem. 1981 May 25;256(10):4734-40
pubmed: 7014556
FEBS Lett. 1987 Apr 20;214(2):295-300
pubmed: 2436945
Toxins (Basel). 2018 Dec 27;11(1):
pubmed: 30591658
Biochem Pharmacol. 2013 Jun 1;85(11):1663-71
pubmed: 23567999
Toxicon. 1998 Apr;36(4):571-88
pubmed: 9643470
Pain Med. 2015 Jul;16(7):1265-77
pubmed: 25645109
Neurosci Lett. 1981 Aug 7;25(1):57-62
pubmed: 6269031
Biochemistry. 1995 Apr 18;34(15):4913-8
pubmed: 7711013
J Biol Chem. 1985 Nov 25;260(27):14589-95
pubmed: 3932357
J Biol Chem. 1996 Mar 29;271(13):7522-8
pubmed: 8631783
J Anal Toxicol. 2007 Jun;31(5):237-53, 8A-9A
pubmed: 17579968
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):1059-1064
pubmed: 30593566
Nat Rev Drug Discov. 2015 Oct;14(10):721-31
pubmed: 26361349
Acta Physiol (Oxf). 2019 Aug;226(4):e13279
pubmed: 30957955
Mar Drugs. 2014 Dec 17;12(12):6058-101
pubmed: 25522317
Toxicon. 1985;23(2):277-82
pubmed: 4024137
J Neurochem. 1989 Apr;52(4):1260-9
pubmed: 2538565
Arch Biochem Biophys. 1978 Oct;190(2):539-48
pubmed: 718167
J Cardiovasc Pharmacol. 2005 Aug;46(2):141-6
pubmed: 16044024
Biochemistry. 1984 Oct 23;23(22):5087-90
pubmed: 6509012
Ann N Y Acad Sci. 1998 May 13;841:596-605
pubmed: 9668304
Arch Biochem Biophys. 1982 Oct 1;218(1):329-34
pubmed: 7149738
Proc Biol Sci. 2004 Jun 7;271(1544):1165-74
pubmed: 15306367
Science. 1985 Dec 20;230(4732):1338-43
pubmed: 4071055
J Biol Chem. 2010 May 14;285(20):14882-9
pubmed: 20220134
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8
pubmed: 25605914
Biomaterials. 2015 Feb;42:52-65
pubmed: 25542793
Toxicon. 2013 Feb;62:19-26
pubmed: 23010164
J Biol Chem. 2003 Jan 10;278(2):757-64
pubmed: 12384509
J Neurosci. 1996 Apr 15;16(8):2612-23
pubmed: 8786437
FASEB J. 2015 Mar;29(3):1011-8
pubmed: 25466886
Biochemistry. 1997 May 27;36(21):6469-74
pubmed: 9174364
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3227-32
pubmed: 26957604
BMC Genomics. 2016 May 26;17:401
pubmed: 27229931
J Molluscan Stud. 2015 Feb;81(1):1-23
pubmed: 26300576
Nat Neurosci. 2016 Sep;19(9):1218-24
pubmed: 27399842
Adv Drug Deliv Rev. 1997 Jun 9;26(1):3-15
pubmed: 10837528
Neuron. 1992 Jul;9(1):69-77
pubmed: 1352986
Biochemistry. 1998 Nov 17;37(46):16019-25
pubmed: 9819194
Eur J Pharmacol. 1988 Mar 29;148(2):261-7
pubmed: 3378575
Eur J Pharmacol. 2002 Sep 20;451(3):279-86
pubmed: 12242089
PLoS One. 2019 Mar 11;14(3):e0213751
pubmed: 30856233