Impact of Chromosome 9 Numerical Imbalances in Oral Squamous Cell Carcinoma: A Pilot Grid-Based Centromere Analysis.
carcinoma
chromosome
grid
microscopy
oral
polysomy
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
21 Jul 2020
21 Jul 2020
Historique:
received:
16
06
2020
revised:
09
07
2020
accepted:
14
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Oral squamous cell carcinoma (OSCC) is considered an aggressive malignancy, mainly due to its increased propensity to provide local and distant lymph node metastases. Gross chromosome instability (CI; polysomy/aneuploidy/monosomy), combined or not with specific gene alterations, is implicated in the development and progression of solid malignancies, including OSCC. In order to further study the relationship between these genetic alterations and the aggressive biological behavior of OSCCs, we investigated the frequency and impact of chromosome 9 numerical imbalances in these tumors. Fifty (
Identifiants
pubmed: 32708098
pii: diagnostics10070501
doi: 10.3390/diagnostics10070501
pmc: PMC7400425
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Hellenic Foundation for Research and Innovation (H.F.R.I.)
ID : First Call for H.F.R.I. Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment grant"
Références
Oral Oncol. 2002 Apr;38(3):266-73
pubmed: 11978549
Arch Pathol Lab Med. 2004 Jun;128(6):627-33
pubmed: 15163239
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan;107(1):81-91
pubmed: 19101490
Head Neck. 2000 Jul;22(4):328-35
pubmed: 10862014
Nat Genet. 2003 Aug;34(4):369-76
pubmed: 12923544
Cancer Med. 2014 Oct;3(5):1170-84
pubmed: 25060540
Mod Pathol. 2007 Oct;20(10):1028-35
pubmed: 17673923
Anticancer Res. 2018 Oct;38(10):5805-5810
pubmed: 30275203
Oral Oncol. 2017 Jul;70:23-28
pubmed: 28622887
J BUON. 2012 Jul-Sep;17(3):593-9
pubmed: 23033306
Clin Cancer Res. 2014 Jul 15;20(14):3842-8
pubmed: 24874835
Oral Oncol. 2011 Jul;47(7):571-6
pubmed: 21592845
Ann Oncol. 2010 May;21 Suppl 5:v184-6
pubmed: 20555077
Nat Rev Clin Oncol. 2015 Jan;12(1):11-26
pubmed: 25403939
BMC Cancer. 2010 May 06;10:182
pubmed: 20459605
Cytometry A. 2008 Apr;73(4):305-11
pubmed: 18163473
J Dent Res. 2009 May;88(5):427-32
pubmed: 19493885
Oral Dis. 2020 Jun 12;:
pubmed: 32531817
Oral Oncol. 2004 Apr;40(4):409-17
pubmed: 14969820
Cytogenet Genome Res. 2003;101(2):106-12
pubmed: 14610349
Oral Oncol. 2019 Jun;93:59-65
pubmed: 31109697
J Oral Pathol Med. 2016 Feb;45(2):83-8
pubmed: 26260282
J Oral Pathol Med. 2019 May;48(5):421-423
pubmed: 30849196
Nature. 2009 Apr 9;458(7239):719-24
pubmed: 19360079
Pathol Int. 2017 Jan;67(1):24-31
pubmed: 27891686
Oral Oncol. 2017 Mar;66:14-21
pubmed: 28249643