Optimizing Preparative Regimen for Umbilical Cord Blood Transplantation in Adult Acute Leukemia Patients: Acute Lymphoblastic Leukemia Requires Myeloablative Conditioning but Not Acute Myeloid Leukemia.

acute lymphoblastic leukemia acute myeloid leukemia conditioning cord blood transplantation

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
21 Jul 2020
Historique:
received: 26 05 2020
revised: 07 07 2020
accepted: 17 07 2020
entrez: 26 7 2020
pubmed: 28 7 2020
medline: 28 7 2020
Statut: epublish

Résumé

Cord blood transplantation (CBT) is a valuable alternative to bone marrow transplantation in adults without readily available donors. We conducted this study to investigate the feasibility of CBT for adult patients with acute leukemia with regards to impact of different conditioning and graft-versus-host disease (GVHD) prophylaxis regimens on clinical outcomes. From 16 centers in Korea, 41 acute myeloid leukemia (AML) and 29 ALL (acute lymphoblastic leukemia) patients undergoing CBT were enrolled. For AML patients, the neutrophil engraftment was observed in 87.5% of reduced intensity conditioning (RIC) and 72.0% of myeloablative conditioning (MAC) (

Identifiants

DOI: 10.3390/jcm9072310 PMID: 32708168 PMC: PMC7408460
pubmed: 32708168
pii: jcm9072310
doi: 10.3390/jcm9072310
pmc: PMC7408460
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Ja Min Byun (JM)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongro-gu, Seoul 03080, Korea.
ORCID: 0000-0003-1780-5553

Junshik Hong (J)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongro-gu, Seoul 03080, Korea.

Doyeun Oh (D)

Department of Internal Medicine, CHA University School of Medicine, Seongnam 13496, Korea.
ORCID: 0000-0002-6981-3144

Ho-Young Yhim (HY)

Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, Korea.

Young Rok Do (YR)

Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 42601, Korea.

Joon Seong Park (JS)

Department of Hematology-Oncology, Ajou University School of Medicine, Suwon 16499, Korea.

Chul Won Jung (CW)

Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Deok-Hwan Yang (DH)

Division of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea.

Jong-Ho Won (JH)

Division of Hematology and Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.

Hong Ghi Lee (HG)

Division of Hematology-Oncology, Department of Internal Medicine, Konkuk University Medical Center, Seoul 05030, Korea.

Joon Ho Moon (JH)

Department of Hematology and Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu 41944, Korea.

Yeung-Chul Mun (YC)

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 07985, Korea.

Deog-Yeon Jo (DY)

Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon 35015, Korea.

Jae Joon Han (JJ)

Department of Hematology and Medical Oncology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.

Je-Hwan Lee (JH)

Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Jae Hoon Lee (JH)

Division of Hematology, Department of Internal Medicine, Gachon University College of Medicine Gil Medical Center, Incheon 21565, Korea.

Junglim Lee (J)

Division of Hematology and Medical Oncology, Department of Internal Medicine, Daegu Fatima Hospital, 99, Ayang-ro, Dong-gu, Daegu 41199, Korea.

Sung-Soo Yoon (SS)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongro-gu, Seoul 03080, Korea.
ORCID: 0000-0003-2591-7459

Classifications MeSH