Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia.
CCR1
CCR2
CD19+CD5+ lymphocytes
CD38
CLL
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
21 Jul 2020
21 Jul 2020
Historique:
received:
16
06
2020
revised:
08
07
2020
accepted:
17
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Chemokines and their receptors direct migration and infiltration of immune cells. CCR1 and CCR2 maintain sequence similarity and respond to a number of the same chemokines secreted in lymphoid organs. Expression of CD38 on leukemic cells has been associated with poor clinical outcomes in patients with chronic lymphocytic leukemia (CLL) and is considered as the negative predictor of progression. In our study of newly diagnosed CLL patients, which included 39 CD38-positive and 22 CD38-negative patients, CCR1 and/or CCR2 were always detected, using flow cytometry, on the peripheral blood (PB) CD19
Identifiants
pubmed: 32708233
pii: jcm9072312
doi: 10.3390/jcm9072312
pmc: PMC7408836
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Latvijas Zinātnes Padome
ID : No. 651/2014
Organisme : Latvijas Zinātnes Padome
ID : No. lzp-2018/1-0156
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