Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer.

HNSCC immune regulation liquid biopsy tumor-derived exosomes

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
21 Jul 2020
Historique:
received: 02 07 2020
revised: 17 07 2020
accepted: 18 07 2020
entrez: 26 7 2020
pubmed: 28 7 2020
medline: 28 7 2020
Statut: epublish

Résumé

Plasma-derived exosomes of head and neck squamous cell carcinoma (HNSCC) patients carry inhibitory factors mediating immune suppression. Separation of tumor-derived exosomes (TEX) and non-TEX may assist in a better understanding of their respective parental cells. Here, we evaluate the impact of TEX or hematopoietic-derived exosomes on immune suppression. We evaluated apoptosis in CD8+ T cells, conversion of CD4+ T cells to regulatory T cells (T

Identifiants

pubmed: 32708274
pii: cancers12071997
doi: 10.3390/cancers12071997
pmc: PMC7409343
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Clin Cancer Res. 2002 Aug;8(8):2553-62
pubmed: 12171883
Expert Rev Mol Diagn. 2018 Dec;18(12):1029-1040
pubmed: 30406709
Br J Cancer. 2013 Nov 12;109(10):2629-35
pubmed: 24169351
Clin Cancer Res. 2018 Feb 15;24(4):896-905
pubmed: 29233903
Clin Cancer Res. 2006 Jul 1;12(13):3890-5
pubmed: 16818683
J Extracell Vesicles. 2016 Mar 24;5:29289
pubmed: 27018366
Clin Exp Immunol. 2014 Aug;177(2):531-43
pubmed: 24749746
J Cell Sci. 2013 Dec 15;126(Pt 24):5553-65
pubmed: 24105262
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18538-43
pubmed: 16344461
Adv Clin Chem. 2016;74:103-41
pubmed: 27117662
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Oncoimmunology. 2019 Apr 24;8(7):1593805
pubmed: 31143513
Cell Mol Neurobiol. 2016 Apr;36(3):301-12
pubmed: 27053351
Am J Pathol. 2014 Jan;184(1):28-41
pubmed: 24269592
Future Oncol. 2017 Dec;13(28):2583-2592
pubmed: 29198150
Oncoimmunology. 2020 Apr 7;9(1):1747732
pubmed: 32313730
Eur J Immunol. 2017 Jun;47(6):946-953
pubmed: 28475283
Cancer Res. 2012 May 1;72(9):2162-71
pubmed: 22549946
Clin Exp Immunol. 2017 Sep;189(3):259-267
pubmed: 28369805
J Immunol. 2011 Jul 15;187(2):676-83
pubmed: 21677139
J Clin Oncol. 2013 Mar 1;31(7):845-52
pubmed: 23182993
Neuro Oncol. 2016 Apr;18(4):497-506
pubmed: 26385614
N Engl J Med. 2005 Dec 22;353(25):2654-66
pubmed: 16371631
Oncoimmunology. 2016 Feb 26;5(2):e1082703
pubmed: 27057473
N Engl J Med. 2004 May 6;350(19):1937-44
pubmed: 15128893
Cancer Res. 2017 Dec 1;77(23):6480-6488
pubmed: 29162616
Clin Exp Immunol. 2018 Jun;192(3):271-283
pubmed: 29431869
Cancer Res. 2007 Sep 15;67(18):8865-73
pubmed: 17875728
Sci Rep. 2016 Feb 04;6:20254
pubmed: 26842680
Sci Rep. 2020 Jan 9;10(1):92
pubmed: 31919420
Clin Cancer Res. 2018 Jan 1;24(1):6-13
pubmed: 28751445
Clin Cancer Res. 2017 Aug 15;23(16):4843-4854
pubmed: 28400428
Immunol Lett. 2018 Apr;196:22-32
pubmed: 29366662
Clin Exp Immunol. 2018 Oct;194(1):67-78
pubmed: 30229863

Auteurs

Inga J Beccard (IJ)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Linda Hofmann (L)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Jan C Schroeder (JC)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Sonja Ludwig (S)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, 68167 Mannheim, Germany.

Simon Laban (S)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Cornelia Brunner (C)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Ramin Lotfi (R)

Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Services Baden-Württemberg-Hessen, 89081 Ulm, Germany.
Institute for Transfusion Medicine, University Hospital Ulm, 89081 Ulm, Germany.

Thomas K Hoffmann (TK)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Edwin K Jackson (EK)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

Patrick J Schuler (PJ)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Marie-Nicole Theodoraki (MN)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany.

Classifications MeSH