EPAC in Vascular Smooth Muscle Cells.
Animals
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Guanine Nucleotide Exchange Factors
/ genetics
Humans
Mitochondria
/ genetics
Muscle Contraction
/ genetics
Muscle, Smooth, Vascular
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
Reactive Oxygen Species
/ metabolism
Signal Transduction
/ genetics
EPAC
ROS
cAMP
cardiovascular disease
phenotypic switch
vascular smooth muscle cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jul 2020
21 Jul 2020
Historique:
received:
17
06
2020
revised:
09
07
2020
accepted:
19
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
5
3
2021
Statut:
epublish
Résumé
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over-proliferate and migrate from the tunica media to the tunica interna, contributing to the occlusion of blood vessels. Since their discovery as effector proteins of cyclic adenosine 3',5'-monophosphate (cAMP), exchange proteins activated by cAMP (EPACs) have been shown to play vital roles in a plethora of pathways in different cell systems. While extensive research to identify the role of EPAC in the vasculature has been conducted, much remains to be explored to resolve the reported discordance in EPAC's effects. In this paper, we review the role of EPAC in VSMCs, namely its regulation of the vascular tone and phenotypic switching, with the likely involvement of reactive oxygen species (ROS) in the interplay between EPAC and its targets/effectors.
Identifiants
pubmed: 32708284
pii: ijms21145160
doi: 10.3390/ijms21145160
pmc: PMC7404248
pii:
doi:
Substances chimiques
Guanine Nucleotide Exchange Factors
0
RAPGEF3 protein, human
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : American University of Beirut
ID : MPP 320133
Organisme : United Arab Emirates University
ID : 31S398-UPAR
Références
J Physiol. 2010 May 15;588(Pt 10):1747-62
pubmed: 20351047
Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H69-76
pubmed: 15345481
Cells. 2019 Nov 16;8(11):
pubmed: 31744111
Front Pharmacol. 2018 Jun 28;9:688
pubmed: 30002626
Mol Cell Biol. 2005 Jan;25(1):136-46
pubmed: 15601837
Biokhimiia. 1985 Sep;50(9):1546-52
pubmed: 2996639
Front Pharmacol. 2016 Nov 16;7:438
pubmed: 27899893
Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H243-50
pubmed: 15764673
FEBS Lett. 2010 May 17;584(10):2033-42
pubmed: 20178789
PLoS One. 2013 Jul 04;8(7):e67925
pubmed: 23861833
Pathol Res Pract. 2018 Jul;214(7):1045-1050
pubmed: 29789158
Cardiovasc Res. 2008 Jul 15;79(2):341-51
pubmed: 18440987
Circ Res. 2004 May 28;94(10):1359-66
pubmed: 15087422
Curr Hypertens Rep. 2003 Feb;5(1):66-72
pubmed: 12530938
Stem Cells Dev. 2015 Nov 1;24(21):2513-24
pubmed: 26192163
Nat Cell Biol. 2000 Dec;2(12):E231-6
pubmed: 11146675
Circ Res. 2006 May 12;98(9):1141-50
pubmed: 16574903
Cell Physiol Biochem. 2012;30(1):247-58
pubmed: 22759971
J Physiol. 2009 Jun 1;587(Pt 11):2537-53
pubmed: 19359365
J Clin Invest. 1992 Feb;89(2):507-11
pubmed: 1531345
J Biol Chem. 2011 May 13;286(19):16681-92
pubmed: 21454546
Vascul Pharmacol. 2020 Aug;131:106690
pubmed: 32407896
Vascul Pharmacol. 2018 Dec;111:15-21
pubmed: 30227233
Circ Res. 2006 May 12;98(9):1159-67
pubmed: 16574904
J Biol Chem. 1998 May 1;273(18):11362-9
pubmed: 9556631
Mol Cell Biol. 2001 Jun;21(11):3671-83
pubmed: 11340161
J Mol Biol. 2013 Aug 9;425(15):2782-94
pubmed: 23659792
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1547-55
pubmed: 18689492
J Biol Chem. 2008 Feb 22;283(8):4464-8
pubmed: 18063584
Nucleic Acids Res. 2004 Apr 23;32(7):2281-5
pubmed: 15107496
Sci Rep. 2016 Sep 16;6:33407
pubmed: 27634335
Pflugers Arch. 2013 Oct;465(10):1397-407
pubmed: 23604972
Breast Cancer Res Treat. 2015 Jul;152(1):17-28
pubmed: 26022351
J Mol Cell Cardiol. 2012 Feb;52(2):323-9
pubmed: 21888909
Sci Adv. 2020 Jan 01;6(1):eaay3566
pubmed: 31911948
Circ Res. 2004 May 28;94(10):1367-74
pubmed: 15087420
Front Physiol. 2012 Oct 29;3:409
pubmed: 23112775
J Biol Chem. 1968 Jul 10;243(13):3763-5
pubmed: 4298072
Science. 1998 Dec 18;282(5397):2275-9
pubmed: 9856955
J Mol Cell Cardiol. 2014 Jul;72:9-19
pubmed: 24534707
J Physiol. 2009 Jul 15;587(Pt 14):3639-50
pubmed: 19491242
Biochem Pharmacol. 2015 Jun 15;95(4):263-78
pubmed: 25931148
Kidney Int. 2011 Jun;79(12):1277-88
pubmed: 21490586
J Cell Physiol. 2009 Jun;219(3):652-8
pubmed: 19170062
J Physiol. 2013 Mar 1;591(5):1235-50
pubmed: 23230233
J Mol Cell Cardiol. 2012 Feb;52(2):351-8
pubmed: 21600214
Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1495-500
pubmed: 15371261
Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C499-511
pubmed: 22621783
Blood. 2005 Mar 1;105(5):1950-5
pubmed: 15374886
Circ Res. 2003 Mar 7;92(4):411-8
pubmed: 12600888
Circ Res. 1998 May 4;82(8):852-61
pubmed: 9576105
J Biol Chem. 2008 Oct 17;283(42):28702-9
pubmed: 18697745
Sci Rep. 2016 Nov 10;6:36552
pubmed: 27830723
Mol Cell Biol. 2008 Dec;28(23):7109-25
pubmed: 18824540
Mol Pharmacol. 1997 May;51(5):711-20
pubmed: 9145909
J Biol Chem. 2000 Jul 7;275(27):20829-36
pubmed: 10777494
J Biol Chem. 2009 Aug 7;284(32):21569-79
pubmed: 19531490
J Biol Chem. 2000 Jul 14;275(28):21722-9
pubmed: 10783386
Curr Hypertens Rep. 2020 Feb 29;22(3):23
pubmed: 32114652
J Clin Invest. 2006 Nov;116(11):3026-34
pubmed: 17080198
J Biol Chem. 2002 Jul 19;277(29):26581-6
pubmed: 12000763
Am J Physiol. 1996 Feb;270(2 Pt 2):H710-22
pubmed: 8779849
Hypertension. 1992 Aug;20(2):129-37
pubmed: 1639454
Cell Calcium. 1990 Apr;11(4):261-8
pubmed: 2163283
Physiol Rev. 2013 Jul;93(3):1317-542
pubmed: 23899566
Circ Res. 2016 Mar 4;118(5):881-97
pubmed: 26941424
Vascul Pharmacol. 2020 Jan;124:106600
pubmed: 31629918
Biochem Soc Trans. 2014 Feb;42(1):89-97
pubmed: 24450633
Circ Res. 2007 Oct 12;101(8):768-76
pubmed: 17717302
J Biol Chem. 2012 Nov 9;287(46):38705-15
pubmed: 23012358
J Cell Physiol. 2012 Nov;227(11):3585-92
pubmed: 22287273
Cardiovasc Res. 2011 Apr 1;90(1):148-56
pubmed: 21109603
J Vasc Res. 2000 Nov-Dec;37(6):556-67
pubmed: 11146410
Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C829-45
pubmed: 23864608
Nat Rev Cardiol. 2019 Dec;16(12):727-744
pubmed: 31243391
Vascul Pharmacol. 2014 Mar;60(3):95-101
pubmed: 24469067
Anticancer Res. 2014 Jul;34(7):3447-55
pubmed: 24982353
Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1486-94
pubmed: 24790136
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1955-61
pubmed: 17644575
Hypertension. 2000 Jan;35(1 Pt 2):237-43
pubmed: 10642304
Endocrinology. 2010 May;151(5):2151-61
pubmed: 20233795
Cardiovasc Res. 2015 Sep 1;107(4):546-55
pubmed: 26092100
Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H59-67
pubmed: 12946937
Physiol Rev. 2018 Apr 1;98(2):919-1053
pubmed: 29537337
J Physiol Sci. 2019 Mar;69(2):175-184
pubmed: 30084082
J Physiol. 2013 Oct 15;591(20):5107-23
pubmed: 23959673
J Biol Chem. 2004 Aug 13;279(33):34496-504
pubmed: 15194681
J Mol Cell Cardiol. 2011 Jan;50(1):87-98
pubmed: 20971121
Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2373-8
pubmed: 11073840
Pharmacol Rev. 2013 Feb 27;65(2):670-709
pubmed: 23447132
Cell Signal. 2009 Jun;21(6):906-15
pubmed: 19385062
Nat Med. 1997 Jul;3(7):775-9
pubmed: 9212106
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H266-72
pubmed: 18487435
J Biol Chem. 2012 Jul 13;287(29):24064-76
pubmed: 22661704
Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1075-83
pubmed: 10749700
Nature. 1998 Dec 3;396(6710):474-7
pubmed: 9853756
Int J Mol Sci. 2017 Jan 13;18(1):
pubmed: 28098754
J Pathol. 2000 Feb;190(3):300-9
pubmed: 10685064
Cardiovasc Res. 2006 Jul 15;71(2):216-25
pubmed: 16616906
Genomics. 2001 Nov;78(1-2):91-8
pubmed: 11707077
Nature. 1998 Jul 23;394(6691):337-43
pubmed: 9690470
Cardiovasc Res. 2015 May 1;106(2):272-83
pubmed: 25587046
J Physiol. 2010 Oct 15;588(Pt 20):3983-4005
pubmed: 20736418
J Biol Chem. 2014 Jul 25;289(30):20939-52
pubmed: 24914207
Life Sci. 2016 Jun 15;155:102-9
pubmed: 27142830
Am J Physiol. 1990 Jul;259(1 Pt 1):C3-18
pubmed: 2164782
Biochem J. 2003 Nov 1;375(Pt 3):517-29
pubmed: 12940771
J Mol Cell Cardiol. 2016 Jan;90:1-10
pubmed: 26625714
Biochem Biophys Res Commun. 1996 Mar 27;220(3):658-63
pubmed: 8607821
J Appl Physiol (1985). 2001 Aug;91(2):973-83
pubmed: 11457816
Cell Stem Cell. 2008 Apr 10;2(4):380-91
pubmed: 18397757
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2617-25
pubmed: 26427796
J Cell Biochem. 2009 Nov 1;108(4):998-1011
pubmed: 19725049
Blood. 2009 Nov 12;114(20):4592-600
pubmed: 19710505
Biochem Pharmacol. 2017 Dec 1;145:94-101
pubmed: 28912066