Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia.
CMV
HLA
KIR
acute leukemia
natural killer cells
repertoire
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Jul 2020
16 Jul 2020
Historique:
received:
22
06
2020
revised:
10
07
2020
accepted:
13
07
2020
entrez:
26
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Natural killer (NK) cells are key cytotoxic effectors against malignant cells. Polygenic and polymorphic Killer cell Immunoglobulin-like Receptor (KIR) and HLA genes participate in the structural and functional formation of the NK cell repertoire. In this study, we extensively investigated the anti-leukemic potential of NK cell subsets, taking into account these genetic parameters and cytomegalovirus (CMV) status. Hierarchical clustering analysis of NK cell subsets based on NKG2A, KIR, CD57 and NKG2C markers from 68 blood donors identified donor clusters characterized by a specific phenotypic NK cell repertoire linked to a particular immunogenetic KIR and HLA profile and CMV status. On the functional side, acute lymphoblastic leukemia (ALL) was better recognized by NK cells than acute myeloid leukemia (AML). However, a broad inter-individual disparity of NK cell responses exists against the same leukemic target, highlighting bad and good NK responders. The most effective NK cell subsets against different ALLs expressed NKG2A and represented the most frequent subset in the NK cell repertoire. In contrast, minority CD57
Identifiants
pubmed: 32708751
pii: cancers12071927
doi: 10.3390/cancers12071927
pmc: PMC7409189
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Immunol Lett. 2013 Sep-Oct;155(1-2):11-3
pubmed: 24076315
J Clin Invest. 2019 Sep 3;129(9):3499-3510
pubmed: 31478911
Immunol Rev. 2015 Sep;267(1):1-5
pubmed: 26284467
Eur J Immunol. 2004 Jun;34(6):1673-9
pubmed: 15162437
N Engl J Med. 2020 Feb 6;382(6):545-553
pubmed: 32023374
Leukemia. 2005 May;19(5):835-40
pubmed: 15744340
Nature. 2019 Aug;572(7768):254-259
pubmed: 31316209
Oncoimmunology. 2018 Jul 11;7(9):e1470730
pubmed: 30228939
Cell. 2018 Jan 25;172(3):534-548.e19
pubmed: 29275861
J Immunol. 2019 Oct 15;203(8):2301-2309
pubmed: 31519864
Blood. 2018 Jan 11;131(2):247-262
pubmed: 28986344
J Immunol. 2013 Nov 1;191(9):4778-88
pubmed: 24078689
Nature. 1998 Feb 19;391(6669):795-9
pubmed: 9486650
Curr Opin Virol. 2016 Feb;16:15-23
pubmed: 26590692
Front Immunol. 2016 Dec 15;7:607
pubmed: 28018364
Cancer Immunol Res. 2017 Aug;5(8):654-665
pubmed: 28637877
J Immunol. 2007 Nov 1;179(9):5977-89
pubmed: 17947671
Semin Immunol. 2017 Jun;31:55-63
pubmed: 28943093
Cell Rep. 2019 Nov 19;29(8):2284-2294.e4
pubmed: 31747601
Front Immunol. 2019 Aug 29;10:2078
pubmed: 31555287
Bioinformatics. 2002 Jan;18(1):207-8
pubmed: 11836235
J Immunol. 2009 Jun 1;182(11):6727-35
pubmed: 19454667
J Immunol. 2008 Nov 1;181(9):6010-9
pubmed: 18941190
Semin Immunol. 2014 Apr;26(2):173-9
pubmed: 24613727
Blood. 2013 Apr 4;121(14):2678-88
pubmed: 23325834
Blood Adv. 2018 Feb 27;2(4):335-346
pubmed: 29449224
Nat Immunol. 2018 May;19(5):453-463
pubmed: 29632329
Semin Cancer Biol. 1991 Oct;2(5):295-309
pubmed: 1773046
J Immunol. 2012 Nov 15;189(10):5082-8
pubmed: 23077239
J Immunol Methods. 2004 Nov;294(1-2):15-22
pubmed: 15604012
Curr Opin Immunol. 2016 Feb;38:52-8
pubmed: 26686774
Blood. 2016 Dec 8;128(23):2616-2623
pubmed: 27697774
Immunity. 2006 Aug;25(2):331-42
pubmed: 16901727
J Immunol. 2013 Sep 1;191(5):2708-16
pubmed: 23918974
Curr Opin Immunol. 2018 Feb;50:102-111
pubmed: 29413815
Front Immunol. 2013 Feb 01;4:15
pubmed: 23378843
Front Oncol. 2019 Nov 19;9:1217
pubmed: 31803612
Blood. 2005 Mar 1;105(5):2066-73
pubmed: 15536144
Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14725-32
pubmed: 21825173
Front Immunol. 2015 Oct 15;6:479
pubmed: 26528283
Trends Immunol. 2016 Dec;37(12):877-888
pubmed: 27773685
Front Immunol. 2013 Dec 09;4:422
pubmed: 24367364
J Immunol. 2015 Oct 1;195(7):3160-70
pubmed: 26311903
J Immunol. 2015 Oct 1;195(7):3374-81
pubmed: 26320254
Blood. 2010 Nov 11;116(19):3853-64
pubmed: 20696944
Nat Immunol. 2019 Sep;20(9):1129-1137
pubmed: 31358998
Immunol Rev. 2002 Dec;190:40-52
pubmed: 12493005
J Clin Invest. 2019 Jun 18;129(9):3770-3785
pubmed: 31211698
Eur J Immunol. 2008 Dec;38(12):3474-86
pubmed: 19016529
Haematologica. 2014 Jul;99(7):1248-54
pubmed: 24658822
Blood. 2005 May 15;105(10):4135-42
pubmed: 15687235
Cytometry B Clin Cytom. 2017 Mar;92(2):100-114
pubmed: 28054442
Tissue Antigens. 2004 Oct;64(4):462-8
pubmed: 15361123
Immunol Rev. 2015 Sep;267(1):197-213
pubmed: 26284479
J Immunol. 2019 Apr 1;202(7):2141-2152
pubmed: 30787107