Podocyte Integrin-
Animals
Cytoprotection
Diabetic Nephropathies
/ prevention & control
Endothelial Protein C Receptor
/ physiology
GTP-Binding Protein alpha Subunits, G12-G13
/ physiology
HEK293 Cells
Humans
Integrin beta3
/ physiology
Mice
Mice, Inbred C57BL
Podocytes
/ physiology
Protein C
/ physiology
Receptor, PAR-1
/ physiology
rhoA GTP-Binding Protein
/ physiology
RhoA signaling
activated protein C
coagulation proteases
diabetic nephropathy
integrin αvβ3
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
11
2019
accepted:
30
04
2020
pubmed:
28
7
2020
medline:
3
3
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Diabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease-dependent signaling modulates dNP, in part A combination of The zymogen protein C and aPC bind to podocyte integrin-
Sections du résumé
BACKGROUND
Diabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease-dependent signaling modulates dNP, in part
METHODS
A combination of
RESULTS
The zymogen protein C and aPC bind to podocyte integrin-
Identifiants
pubmed: 32709711
pii: ASN.2019111163
doi: 10.1681/ASN.2019111163
pmc: PMC7460917
doi:
Substances chimiques
Endothelial Protein C Receptor
0
GNA13 protein, human
0
Integrin beta3
0
Protein C
0
Receptor, PAR-1
0
GTP-Binding Protein alpha Subunits, G12-G13
EC 3.6.5.1
rhoA GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1762-1780Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL101917
Pays : United States
Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
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