Impact of Galectins in Resistance to Anticancer Therapies.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
16
05
2020
revised:
27
06
2020
accepted:
22
07
2020
pubmed:
28
7
2020
medline:
15
12
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Galectins are an endogenous family of β-galactoside-binding proteins that play complex and multifaceted roles at various stages of cancer progression, including modulation of tumor cell proliferation, signaling, adhesion, migration, invasion, epithelial-mesenchymal transition, angiogenesis, and immune escape. Recently, galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies. Here, we present an integrated approach to the pleiotropic functions of galectins and discuss their emerging roles with respect to mechanisms of resistance or sensitivity to anticancer therapies. Taken together, these findings suggest that targeting galectins and/or their glycosylated ligands may help to overcome resistance and to increase the clinical efficacy of anticancer strategies.
Identifiants
pubmed: 32709716
pii: 1078-0432.CCR-18-3870
doi: 10.1158/1078-0432.CCR-18-3870
doi:
Substances chimiques
Antineoplastic Agents
0
Galectins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6086-6101Informations de copyright
©2020 American Association for Cancer Research.
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