Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.
Animals
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
DNA, Viral
/ physiology
Exodeoxyribonucleases
/ genetics
HIV-1
/ physiology
Herpesvirus 1, Human
/ physiology
Host-Pathogen Interactions
Humans
Immunity, Innate
Interferon Regulatory Factor-3
/ metabolism
Interferon Type I
/ metabolism
Mice
Nucleotidyltransferases
/ genetics
Phosphoproteins
/ genetics
Phosphorylation
Species Specificity
Virus Replication
HIV-1
HSV-1
T cells
cGAS
innate sensing
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 08 2020
11 08 2020
Historique:
pubmed:
28
7
2020
medline:
2
10
2020
entrez:
26
7
2020
Statut:
ppublish
Résumé
The DNA sensor cGAS catalyzes the production of the cyclic dinucleotide cGAMP, resulting in type I interferon responses. We addressed the functionality of cGAS-mediated DNA sensing in human and murine T cells. Activated primary CD4
Identifiants
pubmed: 32709741
pii: 2002481117
doi: 10.1073/pnas.2002481117
pmc: PMC7431009
doi:
Substances chimiques
DNA, Viral
0
IRF3 protein, human
0
Interferon Regulatory Factor-3
0
Interferon Type I
0
Phosphoproteins
0
Nucleotidyltransferases
EC 2.7.7.-
cGAS protein, human
EC 2.7.7.-
Exodeoxyribonucleases
EC 3.1.-
three prime repair exonuclease 1
EC 3.1.16.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19475-19486Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: W.B. is an employee of IFM Therapeutics.
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