Functional imaging of mitochondria in retinal diseases using flavoprotein fluorescence.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
15
06
2020
accepted:
16
07
2020
revised:
01
07
2020
pubmed:
28
7
2020
medline:
22
6
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Mitochondria are critical for cellular energy production and homeostasis. Oxidative stress and associated mitochondrial dysfunction are integral components of the pathophysiology of retinal diseases, including diabetic retinopathy (DR), age-related macular degeneration, and glaucoma. Within mitochondria, flavoproteins are oxidized and reduced and emit a green autofluorescence when oxidized following blue light excitation. Recently, a noninvasive imaging device was developed to measure retinal flavoprotein fluorescence (FPF). Thus, oxidized FPF can act as a biomarker of mitochondrial dysfunction. This review article describes the literature surrounding mitochondrial FPF imaging in retinal disease. The authors describe the role of mitochondrial dysfunction in retinal diseases, experiments using FPF as a marker of mitochondrial dysfunction in vitro, the three generations of retinal FPF imaging devices, and the peer-reviewed publications that have examined FPF imaging in patients. Finally, the authors report their own study findings. Goals were to establish normative reference levels for FPF intensity and heterogeneity in healthy eyes, to compare between healthy eyes and eyes with diabetes and DR, and to compare across stages of DR. The authors present methods to calculate a patient's expected FPF values using baseline characteristics. FPF intensity and heterogeneity were elevated in diabetic eyes compared to age-matched control eyes, and in proliferative DR compared to diabetic eyes without retinopathy. In diabetic eyes, higher FPF heterogeneity was associated with poorer visual acuity. In conclusion, while current retinal imaging modalities frequently focus on structural features, functional mitochondrial imaging shows promise as a metabolically targeted tool to evaluate retinal disease. 摘要: 线粒体对细胞能量的产生和内环境稳态至关重要。视网膜疾病如糖尿病视网膜病变 (diabetic retinopathy, DR) 、年龄相关性黄斑变性和青光眼的病理生理改变均涉及氧化应激和相关线粒体功能障碍。在线粒体内, 由于黄素蛋白被氧化和还原, 在蓝光激发下被氧化的黄素蛋白可产生自发绿色荧光。近年来, 一种非侵入性的可检测视网膜黄素蛋白荧光 (flavoprotein fluorescence, FPF) 的成像装置被开发。因此, 氧化的FPF可作为线粒体功能障碍的生物学标志物。本综述围绕视网膜疾病中线粒体FPF成像的相关文献展开描述。作者阐述了线粒体功能障碍在视网膜疾病中的作用, 使用FPF作为线粒体功能障碍的标记物的体外实验, 三代视网膜FPF成像设备, 以及经同行评议的对患者行FPF成像的出版物。最后, 作者报告了他们自己的研究结果。旨在建立健康眼中FPF强度和异质性的标准参考水平, 比较健康眼与糖尿病和DR患者的眼, 以及DR的不同阶段核黄素的不同改变。作者提出使用基线特征计算患者预期FPF值的方法。糖尿病患者眼中的FPF强度和异质性高于与年龄相匹配的对照眼, 增殖性DR患者眼中的FPF强度和异质性高于无视网膜病变的糖尿病眼。在糖尿病患者的眼中, FPF异质性越高, 视力越差。综上, 虽然目前视网膜成像模式通常侧重于结构特征, 然而针对线粒体功能的成像技术显示出FPF可作为一种代谢靶向工具以评估视网膜疾病的前景。.
Autres résumés
Type: Publisher
(chi)
摘要: 线粒体对细胞能量的产生和内环境稳态至关重要。视网膜疾病如糖尿病视网膜病变 (diabetic retinopathy, DR) 、年龄相关性黄斑变性和青光眼的病理生理改变均涉及氧化应激和相关线粒体功能障碍。在线粒体内, 由于黄素蛋白被氧化和还原, 在蓝光激发下被氧化的黄素蛋白可产生自发绿色荧光。近年来, 一种非侵入性的可检测视网膜黄素蛋白荧光 (flavoprotein fluorescence, FPF) 的成像装置被开发。因此, 氧化的FPF可作为线粒体功能障碍的生物学标志物。本综述围绕视网膜疾病中线粒体FPF成像的相关文献展开描述。作者阐述了线粒体功能障碍在视网膜疾病中的作用, 使用FPF作为线粒体功能障碍的标记物的体外实验, 三代视网膜FPF成像设备, 以及经同行评议的对患者行FPF成像的出版物。最后, 作者报告了他们自己的研究结果。旨在建立健康眼中FPF强度和异质性的标准参考水平, 比较健康眼与糖尿病和DR患者的眼, 以及DR的不同阶段核黄素的不同改变。作者提出使用基线特征计算患者预期FPF值的方法。糖尿病患者眼中的FPF强度和异质性高于与年龄相匹配的对照眼, 增殖性DR患者眼中的FPF强度和异质性高于无视网膜病变的糖尿病眼。在糖尿病患者的眼中, FPF异质性越高, 视力越差。综上, 虽然目前视网膜成像模式通常侧重于结构特征, 然而针对线粒体功能的成像技术显示出FPF可作为一种代谢靶向工具以评估视网膜疾病的前景。.
Identifiants
pubmed: 32709959
doi: 10.1038/s41433-020-1110-y
pii: 10.1038/s41433-020-1110-y
pmc: PMC7852520
doi:
Substances chimiques
Flavoproteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-92Subventions
Organisme : NEI NIH HHS
ID : T32 EY024236
Pays : United States
Organisme : Research to Prevent Blindness (RPB)
ID : RPB2002RS
Organisme : Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)
ID : T32EY024236
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