Cortical activation abnormalities in bipolar and schizophrenia patients in a combined oddball-incongruence paradigm.
Affective disorders
Attention
Bipolar disorder
Neuroimaging
Schizophrenia
fMRI
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
07
03
2020
accepted:
13
07
2020
pubmed:
28
7
2020
medline:
19
2
2022
entrez:
26
7
2020
Statut:
ppublish
Résumé
Patients with bipolar disorder and schizophrenia often suffer from severe cognitive impairment even during times of remission. This study investigated the pathomechanisms underlying their deficits in cognitive control. A combined oddball-incongruence fMRI task was applied to examine similarities and differences of neural activation patterns between patients and healthy controls. Bipolar and schizophrenia patients demonstrated hyperactivations in the intraparietal cortex during the oddball condition. Furthermore, bipolar patients revealed diagnosis-specific hyperactivation in the left middle frontal gyrus, precentral gyrus, anteroventral prefrontal cortex and orbitofrontal cortex regions compared to schizophrenia patients and healthy individuals. In comparison to healthy controls the patients showed hypoactivations in the inferior frontal junction and ventral pathway during the cognitively more demanding incongruence. Taken together, bipolar patients seem to recruit frontal and parietal areas during the oddball condition to compensate for potential deficits in their attentional network. During more challenging tasks, i.e., the incongruence condition, their compensatory mechanisms seem to collapse leading to hypoactivations in the same frontal areas as well as the ventral pathway.
Identifiants
pubmed: 32710172
doi: 10.1007/s00406-020-01168-1
pii: 10.1007/s00406-020-01168-1
pmc: PMC8563619
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1487-1499Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 1950/5-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 1950/10-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 1950/8-1
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020. The Author(s).
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