Polycyclic aromatic hydrocarbon metabolites and mortality risk in an adult population.
All-cause mortality
Cancer mortality
Cardiovascular mortality
National Health and Nutrition Examination Survey
Polycyclic aromatic hydrocarbons
Journal
Environmental geochemistry and health
ISSN: 1573-2983
Titre abrégé: Environ Geochem Health
Pays: Netherlands
ID NLM: 8903118
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
14
03
2019
accepted:
08
07
2020
pubmed:
28
7
2020
medline:
27
2
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Occupational polycyclic aromatic hydrocarbons (PAHs) exposure has been shown to increase the risk of various cancers and may be associated with carcinogenic mortality. However, no study has explored the relationship between environmental PAH exposure and mortality in general population. The aim of our study was to explore the association between PAH exposure and all-cause, cardiovascular, and cancer mortality in a general US adult population. We analyzed data from the National Health and Nutrition Examination Survey (NHANES 2001-2006) based on the information in this dataset on 692 males and 717 females. PAH exposure was detected using biomarkers from urine samples. Follow-up data on mortality were derived from initial examination of the subjects until death or 31 December 2006 in the NHANES database. We calculated hazard ratios (HRs) of PAH metabolites among all-cause, cardiovascular, and cancer mortality using the multivariate Cox proportional hazards regression model after adjusting for covariates. Among males, 3-phenanthrene was positively associated with increased risk of all-cause mortality (HR 1.043, 95%CI 1.019-1.066). Female participants with higher 2-napthol (HR 1.043, 95%CI 1.014-1.072), 3-fluorene (HR 2.159, 95%CI 1.233-3.779), and 1-phenanthrene (HR = 1.259, 95%CI 1.070-1.481) levels had increased all-cause mortality. In addition, high 3-phenanthrene (HR 1.333, 95%CI 1.008-1.763) and 1-phenanthrene (HR 1.463, 95%CI 1.126-1.900) levels increased the risk of cardiovascular mortality. However, there were no significant findings for cancer mortality in both genders. Environmental PAH exposure among the adult population is associated with non-carcinogenic but not cancer mortality. Future studies are warranted to determine the underlying mechanisms related to these findings.
Identifiants
pubmed: 32710234
doi: 10.1007/s10653-020-00663-7
pii: 10.1007/s10653-020-00663-7
doi:
Substances chimiques
Biomarkers
0
Polycyclic Aromatic Hydrocarbons
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-45Références
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