Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).
Citrus
Cohort studies
Cutaneous melanoma
Epidemiology
Keratinocyte cancers
Journal
European journal of epidemiology
ISSN: 1573-7284
Titre abrégé: Eur J Epidemiol
Pays: Netherlands
ID NLM: 8508062
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
11
02
2020
accepted:
16
07
2020
pubmed:
28
7
2020
medline:
16
12
2020
entrez:
26
7
2020
Statut:
ppublish
Résumé
Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific dietary questionnaires. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI). During a mean follow-up of 13.7 years, 8448 skin cancer cases were identified among 270,112 participants. We observed a positive linear dose-response relationship between total citrus intake and skin cancer risk (HR = 1.10, 95% CI 1.03-1.18 in the highest vs. lowest quartile; P
Identifiants
pubmed: 32710289
doi: 10.1007/s10654-020-00666-9
pii: 10.1007/s10654-020-00666-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1057-1067Subventions
Organisme : European Research Council (ERC)
ID : ERC-2009-AdG 232997
Organisme : Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra
ID : Murcia (No. 6236)
Organisme : ISCIII RETIC (RD06/0020) and the Catalan Institute of Oncology (Spain)
ID : RD06/0020
Organisme : Norwegian Cancer Society
ID : 6823329
Organisme : Cancer Research UK
ID : 14136 to EPIC-Norfolk
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C570/A16491
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C8221/A19170 for EPIC-Oxford
Pays : United Kingdom
Organisme : Medical Research Council
ID : 1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford
Pays : United Kingdom
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