An alternative procedure to leukapheresis for peripheral hematopoietic progenitor cell collection in very-low-weight children: A single pediatric center experience.
CD34
autologous transplantation
bloodletting procedure
infants
leukapheresis procedure
peripheral blood stem cell collection
Journal
Journal of clinical apheresis
ISSN: 1098-1101
Titre abrégé: J Clin Apher
Pays: United States
ID NLM: 8216305
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
17
01
2019
revised:
27
02
2020
accepted:
22
06
2020
pubmed:
28
7
2020
medline:
4
11
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
PBSC collection using a blood cell separator in very low weight patients can be frequently complicated by severe adverse effects and technical difficulties. From March 2013 to January 2017, 14 PBSC collections were performed in 12 children weighing less than 10 kg, affected by different solid tumours. PBSC collection was performed with a "homemade" aseptically assembled circuit. The circuit is composed by a 150 mL collection bag connected with a 4 stopcock ramp, perfused with ACD. This circuit allows collection of a specific total blood amount from CVC, depending on CD34 Mean CD34 The procedure of total blood collection without the use of a cell separator is feasible and allows a good PBSC collection without significant side effects in very low-weight children. Moreover, this method could represent a valid and safe alternative to leukapheresis in patients where classic procedure could be difficult to apply.
Sections du résumé
BACKGROUND
BACKGROUND
PBSC collection using a blood cell separator in very low weight patients can be frequently complicated by severe adverse effects and technical difficulties.
MATERIAL AND METHODS
METHODS
From March 2013 to January 2017, 14 PBSC collections were performed in 12 children weighing less than 10 kg, affected by different solid tumours. PBSC collection was performed with a "homemade" aseptically assembled circuit. The circuit is composed by a 150 mL collection bag connected with a 4 stopcock ramp, perfused with ACD. This circuit allows collection of a specific total blood amount from CVC, depending on CD34
RESULTS
RESULTS
Mean CD34
DISCUSSION
CONCLUSIONS
The procedure of total blood collection without the use of a cell separator is feasible and allows a good PBSC collection without significant side effects in very low-weight children. Moreover, this method could represent a valid and safe alternative to leukapheresis in patients where classic procedure could be difficult to apply.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
406-412Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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